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Screening of some European medicinal plants for spasmolytic activity on isolated guinea-pig trachea

Bergendorff, O. LU ; Franzen, C.; Jeppsson, A.-B.; Sterner, O. LU and Waldeck, B. LU (1995) In International Journal of Pharmacognosy 33(4). p.356-358
Abstract
Eight European plants, used traditionally against diseases of the respiratory system, have been assayed for in vitro spasmolytic activity on guinea-pig trachea. The plants were collected or cultivated in the south of Sweden, and both water and 67% methanol extracts of the parts reported to be used in the traditional medicine were prepared and assayed. Five of the species did not show any significant activity at concentrations up to 0.6 mg extract per ml organ bath, the methanol extracts of 2 species (Glechoma hederacea and Hyssopus officinale) showed weak activity, while 0.6 mg/ml of the methanol extract of the aerial parts of Artemisia abrotanum relaxed the tone induced by 0.1 μmol/l carbachol almost (80%) as effectively as 2.2 mmol/l... (More)
Eight European plants, used traditionally against diseases of the respiratory system, have been assayed for in vitro spasmolytic activity on guinea-pig trachea. The plants were collected or cultivated in the south of Sweden, and both water and 67% methanol extracts of the parts reported to be used in the traditional medicine were prepared and assayed. Five of the species did not show any significant activity at concentrations up to 0.6 mg extract per ml organ bath, the methanol extracts of 2 species (Glechoma hederacea and Hyssopus officinale) showed weak activity, while 0.6 mg/ml of the methanol extract of the aerial parts of Artemisia abrotanum relaxed the tone induced by 0.1 μmol/l carbachol almost (80%) as effectively as 2.2 mmol/l terbutaline. (Less)
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Contribution to journal
publication status
published
subject
keywords
artemisia abrotanum extract, plant extract, terbutaline, unclassified drug, animal tissue, controlled study, drug screening, guinea pig, male, medicinal plant, nonhuman, short survey, spasmolysis, Sweden, trachea
in
International Journal of Pharmacognosy
volume
33
issue
4
pages
356 - 358
ISSN
0925-1618
language
English
LU publication?
yes
id
305cf4c1-b5cf-4f60-90d6-51a74cb4d7d5
date added to LUP
2017-06-08 12:07:23
date last changed
2017-08-09 14:22:44
@article{305cf4c1-b5cf-4f60-90d6-51a74cb4d7d5,
  abstract     = {Eight European plants, used traditionally against diseases of the respiratory system, have been assayed for in vitro spasmolytic activity on guinea-pig trachea. The plants were collected or cultivated in the south of Sweden, and both water and 67% methanol extracts of the parts reported to be used in the traditional medicine were prepared and assayed. Five of the species did not show any significant activity at concentrations up to 0.6 mg extract per ml organ bath, the methanol extracts of 2 species (Glechoma hederacea and Hyssopus officinale) showed weak activity, while 0.6 mg/ml of the methanol extract of the aerial parts of Artemisia abrotanum relaxed the tone induced by 0.1 μmol/l carbachol almost (80%) as effectively as 2.2 mmol/l terbutaline.},
  author       = {Bergendorff, O. and Franzen, C. and Jeppsson, A.-B. and Sterner, O. and Waldeck, B.},
  issn         = {0925-1618},
  keyword      = {artemisia abrotanum extract,plant extract,terbutaline,unclassified drug,animal tissue,controlled study,drug screening,guinea pig,male,medicinal plant,nonhuman,short survey,spasmolysis,Sweden,trachea},
  language     = {eng},
  month        = {06},
  number       = {4},
  pages        = {356--358},
  series       = {International Journal of Pharmacognosy},
  title        = {Screening of some European medicinal plants for spasmolytic activity on isolated guinea-pig trachea},
  volume       = {33},
  year         = {1995},
}