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The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study

Sluijs, Ivonne; Forouhi, Nita G.; Beulens, Joline W. J.; van der Schouw, Yvonne T.; Agnoli, Claudia; Arriola, Larraitz; Balkau, Beverley; Barricarte, Aurelio; Boeing, Heiner and Bueno-de-Mesquita, H. Bas, et al. (2012) In American Journal of Clinical Nutrition 96(2). p.382-390
Abstract
Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary... (More)
Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles: Conclusions: This. large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined. fermented dairy product intake with diabetes is suggested, which merits further study. Ant J Clin Nutr 2012;96:382-90. (Less)
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American Journal of Clinical Nutrition
volume
96
issue
2
pages
382 - 390
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000306769700021
  • scopus:84864359760
ISSN
1938-3207
DOI
10.3945/ajcn.111.021907
language
English
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yes
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3789545d-1802-42f0-93d1-807b262cbf31 (old id 3069719)
date added to LUP
2012-10-05 06:58:24
date last changed
2017-11-05 04:17:28
@article{3789545d-1802-42f0-93d1-807b262cbf31,
  abstract     = {Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles: Conclusions: This. large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined. fermented dairy product intake with diabetes is suggested, which merits further study. Ant J Clin Nutr 2012;96:382-90.},
  author       = {Sluijs, Ivonne and Forouhi, Nita G. and Beulens, Joline W. J. and van der Schouw, Yvonne T. and Agnoli, Claudia and Arriola, Larraitz and Balkau, Beverley and Barricarte, Aurelio and Boeing, Heiner and Bueno-de-Mesquita, H. Bas and Clavel-Chapelon, Francoise and Crowe, Francesca L. and de Lauzon-Guillain, Blandine and Drogan, Dagmar and Franks, Paul and Gavrila, Diana and Gonzalez, Carlos and Halkjaer, Jytte and Kaaks, Rudolf and Moskal, Aurelie and Nilsson, Peter and Overvad, Kim and Palli, Domenico and Panico, Salvatore and Quiros, Jose R. and Ricceri, Fulvio and Rinaldi, Sabina and Rolandsson, Olov and Sacerdote, Carlotta and Sanchez, Maria-Jose and Slimani, Nadia and Spijkerman, Annemieke M. W. and Teucher, Birgit and Tjonneland, Anne and Tormo, Maria-Jose and Tumino, Rosario and van der A, Daphne L. and Sharp, Stephen J. and Langenberg, Claudia and Feskens, Edith J. M. and Riboli, Elio and Wareham, Nicholas J.},
  issn         = {1938-3207},
  language     = {eng},
  number       = {2},
  pages        = {382--390},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study},
  url          = {http://dx.doi.org/10.3945/ajcn.111.021907},
  volume       = {96},
  year         = {2012},
}