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Gender-related differences in the burden of non-motor symptoms in Parkinson's disease

Martinez-Martin, Pablo; Pecurariu, Cristian Falup; Odin, Per LU ; van Hilten, Jacobus J.; Antonini, Angelo; Rojo-Abuin, Jose M.; Borges, Vanderci; Trenkwalder, Claudia; Aarsland, Dag and Brooks, David J., et al. (2012) In Journal of Neurology 259(8). p.1639-1647
Abstract
Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. The present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor symptoms scale (NMSS). Assessments for motor impairment and complications, global severity, and health state were also applied. All disease stages were included. No significant gender differences were found for demographic and clinical characteristics. For the entire sample, the most prevalent symptoms were Nocturia (64.88%) and Fatigue (62.78%) and... (More)
Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. The present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor symptoms scale (NMSS). Assessments for motor impairment and complications, global severity, and health state were also applied. All disease stages were included. No significant gender differences were found for demographic and clinical characteristics. For the entire sample, the most prevalent symptoms were Nocturia (64.88%) and Fatigue (62.78%) and the most prevalent affected domains were Sleep/Fatigue (84.02%) and Miscellaneous (82.44%). Fatigue, feelings of nervousness, feelings of sadness, constipation, restless legs, and pain were more common and severe in women. On the contrary, daytime sleepiness, dribbling saliva, interest in sex, and problems having sex were more prevalent and severe in men. Regarding the NMSS domains, Mood/Apathy and Miscellaneous problems (pain, loss of taste or smell, weight change, and excessive sweating) were predominantly affected in women and Sexual dysfunction in men. No other significant differences by gender were observed. To conclude, in this study significant differences between men and women in prevalence and severity of fatigue, mood, sexual and digestive problems, pain, restless legs, and daytime sleepiness were found. Gender-related patterns of NMS involvement may be relevant for clinical trials in PD. (Less)
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Contribution to journal
publication status
published
subject
keywords
Parkinson's disease, Non-motor symptoms, Gender, Prevalence, Burden
in
Journal of Neurology
volume
259
issue
8
pages
1639 - 1647
publisher
Steinkopff
external identifiers
  • wos:000307267300016
  • scopus:84867322109
ISSN
1432-1459
DOI
10.1007/s00415-011-6392-3
language
English
LU publication?
yes
id
cebddff8-ae66-41e9-8d96-d0d25c2dcca9 (old id 3070249)
date added to LUP
2012-10-05 07:12:20
date last changed
2017-10-29 03:47:07
@article{cebddff8-ae66-41e9-8d96-d0d25c2dcca9,
  abstract     = {Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. The present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor symptoms scale (NMSS). Assessments for motor impairment and complications, global severity, and health state were also applied. All disease stages were included. No significant gender differences were found for demographic and clinical characteristics. For the entire sample, the most prevalent symptoms were Nocturia (64.88%) and Fatigue (62.78%) and the most prevalent affected domains were Sleep/Fatigue (84.02%) and Miscellaneous (82.44%). Fatigue, feelings of nervousness, feelings of sadness, constipation, restless legs, and pain were more common and severe in women. On the contrary, daytime sleepiness, dribbling saliva, interest in sex, and problems having sex were more prevalent and severe in men. Regarding the NMSS domains, Mood/Apathy and Miscellaneous problems (pain, loss of taste or smell, weight change, and excessive sweating) were predominantly affected in women and Sexual dysfunction in men. No other significant differences by gender were observed. To conclude, in this study significant differences between men and women in prevalence and severity of fatigue, mood, sexual and digestive problems, pain, restless legs, and daytime sleepiness were found. Gender-related patterns of NMS involvement may be relevant for clinical trials in PD.},
  author       = {Martinez-Martin, Pablo and Pecurariu, Cristian Falup and Odin, Per and van Hilten, Jacobus J. and Antonini, Angelo and Rojo-Abuin, Jose M. and Borges, Vanderci and Trenkwalder, Claudia and Aarsland, Dag and Brooks, David J. and Chaudhuri, Kallol Ray},
  issn         = {1432-1459},
  keyword      = {Parkinson's disease,Non-motor symptoms,Gender,Prevalence,Burden},
  language     = {eng},
  number       = {8},
  pages        = {1639--1647},
  publisher    = {Steinkopff},
  series       = {Journal of Neurology},
  title        = {Gender-related differences in the burden of non-motor symptoms in Parkinson's disease},
  url          = {http://dx.doi.org/10.1007/s00415-011-6392-3},
  volume       = {259},
  year         = {2012},
}