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Randomized clinical trial of the effect of interferon alpha on survival in patients with disseminated midgut carcinoid tumours

Kolby, L; Persson, G; Franzen, S and Ahrén, Bo LU (2003) In British Journal of Surgery 90(6). p.687-693
Abstract
Background: Midgut carcinoid tumours often present with widespread disease making curative surgery impossible. Medical treatment therefore plays a major role in the treatment of these patients. Methods: In this prospective randomized study, the effect of interferon (IFN) alpha on survival and risk of tumour progression was evaluated in 68 patients with midgut carcinoid tumours metastatic to the liver. All patients had undergone primary surgical treatment and hepatic arterial embolization of liver metastases before randomization. Patients were randomized to treatment with either octreotide alone (n = 35) or octreotide in combination with IFN-alpha (n = 33). Results: Forty-one of the 68 patients died during a follow-up period of 33-120... (More)
Background: Midgut carcinoid tumours often present with widespread disease making curative surgery impossible. Medical treatment therefore plays a major role in the treatment of these patients. Methods: In this prospective randomized study, the effect of interferon (IFN) alpha on survival and risk of tumour progression was evaluated in 68 patients with midgut carcinoid tumours metastatic to the liver. All patients had undergone primary surgical treatment and hepatic arterial embolization of liver metastases before randomization. Patients were randomized to treatment with either octreotide alone (n = 35) or octreotide in combination with IFN-alpha (n = 33). Results: Forty-one of the 68 patients died during a follow-up period of 33-120 months, equivalent to a 5-year survival rate of 46.5 per cent. There was no significant difference in survival between patients treated with octreotide alone (5-year survival rate 36.6 per cent) and those given octreotide in combination with IFN-alpha (56.8 per cent). However, patients treated with IFN-alpha had a significantly reduced risk of tumour progression during follow-up (P = 0.008). Conclusion: Addition of IFN-alpha to octreotide may retard tumour growth in patients with midgut carcinoid tumours. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
90
issue
6
pages
687 - 693
publisher
John Wiley & Sons
external identifiers
  • wos:000183615800007
  • pmid:12808615
  • scopus:0037900591
ISSN
1365-2168
DOI
10.1002/bjs.4149
language
English
LU publication?
yes
id
1184298b-363b-4b91-bd7a-c80f0a106dfe (old id 308241)
date added to LUP
2007-09-16 09:54:01
date last changed
2018-10-03 10:46:21
@article{1184298b-363b-4b91-bd7a-c80f0a106dfe,
  abstract     = {Background: Midgut carcinoid tumours often present with widespread disease making curative surgery impossible. Medical treatment therefore plays a major role in the treatment of these patients. Methods: In this prospective randomized study, the effect of interferon (IFN) alpha on survival and risk of tumour progression was evaluated in 68 patients with midgut carcinoid tumours metastatic to the liver. All patients had undergone primary surgical treatment and hepatic arterial embolization of liver metastases before randomization. Patients were randomized to treatment with either octreotide alone (n = 35) or octreotide in combination with IFN-alpha (n = 33). Results: Forty-one of the 68 patients died during a follow-up period of 33-120 months, equivalent to a 5-year survival rate of 46.5 per cent. There was no significant difference in survival between patients treated with octreotide alone (5-year survival rate 36.6 per cent) and those given octreotide in combination with IFN-alpha (56.8 per cent). However, patients treated with IFN-alpha had a significantly reduced risk of tumour progression during follow-up (P = 0.008). Conclusion: Addition of IFN-alpha to octreotide may retard tumour growth in patients with midgut carcinoid tumours.},
  author       = {Kolby, L and Persson, G and Franzen, S and Ahrén, Bo},
  issn         = {1365-2168},
  language     = {eng},
  number       = {6},
  pages        = {687--693},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Randomized clinical trial of the effect of interferon alpha on survival in patients with disseminated midgut carcinoid tumours},
  url          = {http://dx.doi.org/10.1002/bjs.4149},
  volume       = {90},
  year         = {2003},
}