A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human semen coagulum
(2003) In Molecular Human Reproduction 9(6). p.345-350- Abstract
- Human semen coagulum predominantly consists of high molecular mass complexes of the seminal vesicle secreted semenogelin I (SgI) and semenogelin II (SgII). Here we describe a previously unknown variant of the SgI gene that is present at an allele frequency of similar to3% in the Swedish population. It gives rise to a protein with a molecular mass of 43 kDa, SgI(43), which compared with the 50 kDa variant, SgI(50), is lacking a tandem repeat of 60 amino acid residues that was probably deleted by homologous recombination. In spite of the size difference, SgI(43) has many properties in common with SgI(50), such as a very high iso-electric point and susceptibility to proteolytic degradation by prostate-specific antigen. Heterozygous carriers... (More)
- Human semen coagulum predominantly consists of high molecular mass complexes of the seminal vesicle secreted semenogelin I (SgI) and semenogelin II (SgII). Here we describe a previously unknown variant of the SgI gene that is present at an allele frequency of similar to3% in the Swedish population. It gives rise to a protein with a molecular mass of 43 kDa, SgI(43), which compared with the 50 kDa variant, SgI(50), is lacking a tandem repeat of 60 amino acid residues that was probably deleted by homologous recombination. In spite of the size difference, SgI(43) has many properties in common with SgI(50), such as a very high iso-electric point and susceptibility to proteolytic degradation by prostate-specific antigen. Heterozygous carriers of the SgI(43) allele neither show impaired fertility nor do they significantly differ from individuals homozygous for I SgI(50) with respect to sperm parameters such as semen volume, sperm count and fraction of motile spermatozoa. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/308433
- author
- Lundwall, Åke LU ; Giwercman, Aleksander LU ; Ruhayel, Yasir LU ; Giwercman, Yvonne LU ; Lilja, Hans LU ; Halldén, Christer LU and Malm, Johan LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- transglutaminase, semen semenogelin I/II, allele, coagulum, truncated
- in
- Molecular Human Reproduction
- volume
- 9
- issue
- 6
- pages
- 345 - 350
- publisher
- Oxford University Press
- external identifiers
-
- wos:000183575800005
- pmid:12771235
- scopus:0037972509
- ISSN
- 1460-2407
- DOI
- 10.1093/molehr/gag049
- language
- English
- LU publication?
- yes
- id
- f63d99bc-e406-4626-88f7-862a71147ec7 (old id 308433)
- date added to LUP
- 2016-04-01 11:45:36
- date last changed
- 2022-02-03 04:40:37
@article{f63d99bc-e406-4626-88f7-862a71147ec7, abstract = {{Human semen coagulum predominantly consists of high molecular mass complexes of the seminal vesicle secreted semenogelin I (SgI) and semenogelin II (SgII). Here we describe a previously unknown variant of the SgI gene that is present at an allele frequency of similar to3% in the Swedish population. It gives rise to a protein with a molecular mass of 43 kDa, SgI(43), which compared with the 50 kDa variant, SgI(50), is lacking a tandem repeat of 60 amino acid residues that was probably deleted by homologous recombination. In spite of the size difference, SgI(43) has many properties in common with SgI(50), such as a very high iso-electric point and susceptibility to proteolytic degradation by prostate-specific antigen. Heterozygous carriers of the SgI(43) allele neither show impaired fertility nor do they significantly differ from individuals homozygous for I SgI(50) with respect to sperm parameters such as semen volume, sperm count and fraction of motile spermatozoa.}}, author = {{Lundwall, Åke and Giwercman, Aleksander and Ruhayel, Yasir and Giwercman, Yvonne and Lilja, Hans and Halldén, Christer and Malm, Johan}}, issn = {{1460-2407}}, keywords = {{transglutaminase; semen semenogelin I/II; allele; coagulum; truncated}}, language = {{eng}}, number = {{6}}, pages = {{345--350}}, publisher = {{Oxford University Press}}, series = {{Molecular Human Reproduction}}, title = {{A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human semen coagulum}}, url = {{http://dx.doi.org/10.1093/molehr/gag049}}, doi = {{10.1093/molehr/gag049}}, volume = {{9}}, year = {{2003}}, }