Maternal drug use and infant cleft lip/palate with special reference to corticoids
(2003) In The Cleft Palate - Craniofacial Journal 40(6). p.624-628- Abstract
- Objective: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. Design: Register analysis based on prospectively collected information. Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. Main outcome measure: Presence of orofacial cleft in infant. Results: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft... (More)
- Objective: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. Design: Register analysis based on prospectively collected information. Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. Main outcome measure: Presence of orofacial cleft in infant. Results: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft palate (OR = 1.03, 95% CI = 0.79 to 1.36) or with isolated cleft lip with or without cleft palate (OR = 0.86, 95% CI = 0.71 to 1.05). Reported use of multivitamins, folic acid, or 131, was not associated with a decrease in orofacial cleft risk (OR = 1.00, 95% CI = 0.63 to 1.52). ORs above 2 were seen for some drugs: sulfasalazine, naproxen, and anticonvulsants, but only a few exposed cases occurred. An association between glucocorticoid use and infant cleft was indicated and seemed to be strongest for median cleft palate. Conclusion: Maternal drug use seems to play only a small role for the origin of orofacial clefts, at least in Sweden. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/295449
- author
- Källén, Bengt LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sulfasalazine, vitamins, naproxen, glucocorticoid, drugs, cleft lip, cleft palate
- in
- The Cleft Palate - Craniofacial Journal
- volume
- 40
- issue
- 6
- pages
- 624 - 628
- publisher
- SAGE Publications
- external identifiers
-
- wos:000186602200011
- pmid:14577813
- scopus:17644448555
- ISSN
- 1545-1569
- DOI
- 10.1597/02-077
- language
- English
- LU publication?
- yes
- id
- 3087eaa2-3fd4-421f-97fb-03686df15a35 (old id 295449)
- date added to LUP
- 2016-04-01 12:38:31
- date last changed
- 2022-03-29 03:41:24
@article{3087eaa2-3fd4-421f-97fb-03686df15a35,
abstract = {{Objective: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. Design: Register analysis based on prospectively collected information. Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. Main outcome measure: Presence of orofacial cleft in infant. Results: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft palate (OR = 1.03, 95% CI = 0.79 to 1.36) or with isolated cleft lip with or without cleft palate (OR = 0.86, 95% CI = 0.71 to 1.05). Reported use of multivitamins, folic acid, or 131, was not associated with a decrease in orofacial cleft risk (OR = 1.00, 95% CI = 0.63 to 1.52). ORs above 2 were seen for some drugs: sulfasalazine, naproxen, and anticonvulsants, but only a few exposed cases occurred. An association between glucocorticoid use and infant cleft was indicated and seemed to be strongest for median cleft palate. Conclusion: Maternal drug use seems to play only a small role for the origin of orofacial clefts, at least in Sweden.}},
author = {{Källén, Bengt}},
issn = {{1545-1569}},
keywords = {{sulfasalazine; vitamins; naproxen; glucocorticoid; drugs; cleft lip; cleft palate}},
language = {{eng}},
number = {{6}},
pages = {{624--628}},
publisher = {{SAGE Publications}},
series = {{The Cleft Palate - Craniofacial Journal}},
title = {{Maternal drug use and infant cleft lip/palate with special reference to corticoids}},
url = {{http://dx.doi.org/10.1597/02-077}},
doi = {{10.1597/02-077}},
volume = {{40}},
year = {{2003}},
}