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Maternal drug use in early pregnancy and infant cardiovascular defect

Källén, Bengt LU and Olausson, P O (2003) In Reproductive Toxicology 17(3). p.255-261
Abstract
The purpose of the paper is to identify maternal drug use that may be associated with an increased risk for cardiac defects in the offspring. A case-control study was performed with cases (cardiovascular defects without known chromosome anomalies) being identified from three Swedish health registers (n = 5015) and controls being all infants born in Sweden during the period 1 July 1995-2001 (n = 577,730). Information on drug exposure was obtained by interview in early pregnancy. Associations between maternal drug use and infant cardiovascular defect were identified for insulin, antihypertensives, fertility drugs, erythromycin, naproxen, anticonvulsants, nitrofurantoin, clomipramine, and budesonide in nasal preparations. Some of these... (More)
The purpose of the paper is to identify maternal drug use that may be associated with an increased risk for cardiac defects in the offspring. A case-control study was performed with cases (cardiovascular defects without known chromosome anomalies) being identified from three Swedish health registers (n = 5015) and controls being all infants born in Sweden during the period 1 July 1995-2001 (n = 577,730). Information on drug exposure was obtained by interview in early pregnancy. Associations between maternal drug use and infant cardiovascular defect were identified for insulin, antihypertensives, fertility drugs, erythromycin, naproxen, anticonvulsants, nitrofurantoin, clomipramine, and budesonide in nasal preparations. Some of these associations are probably due to confounding from underlying disease or complaint, some may be due to multiple testing, some may be true drug effects. Further studies are needed to verify or reject these associations. (C) 2003 Elsevier Science Inc. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
antihypertensives, fertility drugs, budesonide, clomipramine, nitrofurantoin, naproxen, cardiovascular defect, erythromycin
in
Reproductive Toxicology
volume
17
issue
3
pages
255 - 261
publisher
Elsevier
external identifiers
  • wos:000183437600001
  • scopus:0038485691
ISSN
1873-1708
DOI
10.1016/S0890-6238(03)00012-1
language
English
LU publication?
yes
id
bb94ebbc-d04e-4670-b93d-a31b41eff7b6 (old id 308803)
date added to LUP
2007-09-13 15:28:12
date last changed
2018-02-11 03:56:58
@article{bb94ebbc-d04e-4670-b93d-a31b41eff7b6,
  abstract     = {The purpose of the paper is to identify maternal drug use that may be associated with an increased risk for cardiac defects in the offspring. A case-control study was performed with cases (cardiovascular defects without known chromosome anomalies) being identified from three Swedish health registers (n = 5015) and controls being all infants born in Sweden during the period 1 July 1995-2001 (n = 577,730). Information on drug exposure was obtained by interview in early pregnancy. Associations between maternal drug use and infant cardiovascular defect were identified for insulin, antihypertensives, fertility drugs, erythromycin, naproxen, anticonvulsants, nitrofurantoin, clomipramine, and budesonide in nasal preparations. Some of these associations are probably due to confounding from underlying disease or complaint, some may be due to multiple testing, some may be true drug effects. Further studies are needed to verify or reject these associations. (C) 2003 Elsevier Science Inc. All rights reserved.},
  author       = {Källén, Bengt and Olausson, P O},
  issn         = {1873-1708},
  keyword      = {antihypertensives,fertility drugs,budesonide,clomipramine,nitrofurantoin,naproxen,cardiovascular defect,erythromycin},
  language     = {eng},
  number       = {3},
  pages        = {255--261},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Maternal drug use in early pregnancy and infant cardiovascular defect},
  url          = {http://dx.doi.org/10.1016/S0890-6238(03)00012-1},
  volume       = {17},
  year         = {2003},
}