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Familial risk for lung cancer by histology and age of onset : evidence for recessive inheritance

Hemminki, Kari LU and Li, Xinjun LU (2005) In Heart and Lung: Journal of Acute and Critical Care 31(2). p.15-205
Abstract

The authors used the Swedish Family-Cancer Database to search for evidence for a genetic predisposition in lung cancer. Familial risks in offspring were increased for all lung cancer to 1.77 when a parent was affected with any lung cancers; the comparable risk among siblings was 2.15. At young age, risks between siblings were higher than those between offspring and parents for all histological types of lung cancer. The present data suggest that 1.7% of lung cancers up to age 68 years are heritable and probably due to a high-penetrant recessive gene or genes that predispose to tobacco carcinogens.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Age of Onset, Aged, Child, Child, Preschool, Databases, Factual, Female, Genes, Recessive, Genetic Predisposition to Disease, Humans, Incidence, Infant, Infant, Newborn, Lung Neoplasms/epidemiology, Male, Middle Aged, Nuclear Family, Parents, Siblings, Sweden/epidemiology
in
Heart and Lung: Journal of Acute and Critical Care
volume
31
issue
2
pages
11 pages
publisher
Mosby
external identifiers
  • scopus:14644434427
ISSN
0190-2148
DOI
10.1080/01902140490495606
language
English
LU publication?
no
id
309e29f3-726b-4511-ba0e-ae8a953c68e7
date added to LUP
2019-01-30 11:38:58
date last changed
2019-02-20 11:45:46
@article{309e29f3-726b-4511-ba0e-ae8a953c68e7,
  abstract     = {<p>The authors used the Swedish Family-Cancer Database to search for evidence for a genetic predisposition in lung cancer. Familial risks in offspring were increased for all lung cancer to 1.77 when a parent was affected with any lung cancers; the comparable risk among siblings was 2.15. At young age, risks between siblings were higher than those between offspring and parents for all histological types of lung cancer. The present data suggest that 1.7% of lung cancers up to age 68 years are heritable and probably due to a high-penetrant recessive gene or genes that predispose to tobacco carcinogens.</p>},
  author       = {Hemminki, Kari and Li, Xinjun},
  issn         = {0190-2148},
  keyword      = {Adolescent,Adult,Age of Onset,Aged,Child,Child, Preschool,Databases, Factual,Female,Genes, Recessive,Genetic Predisposition to Disease,Humans,Incidence,Infant,Infant, Newborn,Lung Neoplasms/epidemiology,Male,Middle Aged,Nuclear Family,Parents,Siblings,Sweden/epidemiology},
  language     = {eng},
  number       = {2},
  pages        = {15--205},
  publisher    = {Mosby},
  series       = {Heart and Lung: Journal of Acute and Critical Care},
  title        = {Familial risk for lung cancer by histology and age of onset : evidence for recessive inheritance},
  url          = {http://dx.doi.org/10.1080/01902140490495606},
  volume       = {31},
  year         = {2005},
}