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Comparison of estimated breeding values, daughter yield deviations and de-regressed proofs within a whole genome scan for QTL

Thomsen, H. LU orcid ; Reinsch, N. ; Xu, N. ; Looft, C. ; Grupe, S. ; Kühn, C. ; Brockmann, G. A. ; Schwerin, M. ; Leyhe-Horn, B. and Hiendleder, S. , et al. (2001) In Journal of Animal Breeding and Genetics 118(6). p.357-370
Abstract

An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) as the unit of choice are not available for all traits of interest. The use of de-regressed proofs (DRPFs) of estimated breeding values (EBVs) is an alternative to using daughter yield deviations. The objective of this study was to examine possible differences between DYDs and DRPFs within the use of QTL detection. The pedigree used was part of the granddaughter design of the German QTL effort. Consisting marker maps for livestock species were derived from all available data of 16 German Holstein paternal half-sib families with a total of 872 sires. The number of progeny ranged from... (More)

An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) as the unit of choice are not available for all traits of interest. The use of de-regressed proofs (DRPFs) of estimated breeding values (EBVs) is an alternative to using daughter yield deviations. The objective of this study was to examine possible differences between DYDs and DRPFs within the use of QTL detection. The pedigree used was part of the granddaughter design of the German QTL effort. Consisting marker maps for livestock species were derived from all available data of 16 German Holstein paternal half-sib families with a total of 872 sires. The number of progeny ranged from 19 to 127. A whole genome scan was performed using weighted and unweighted multimarker regression with DYDs, DRPFs and EBVs as dependent variables for the traits milk, fat and protein yields. Results were compared with respect to the number of QTL detected. A similar number of QTL was detected with DRPFs and DYDs. Also, when dependent variables were weighted according to the variance of the trait, a higher number of QTL was detected at the desired level of significance as compared to using unweighted variables.

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publishing date
type
Contribution to journal
publication status
published
in
Journal of Animal Breeding and Genetics
volume
118
issue
6
pages
14 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0035632895
ISSN
0931-2668
DOI
10.1046/j.1439-0388.2001.00302.x
language
English
LU publication?
no
id
30a57fb1-bfd4-4e9e-bbee-f326757a385e
date added to LUP
2018-10-10 13:43:49
date last changed
2022-01-31 06:03:36
@article{30a57fb1-bfd4-4e9e-bbee-f326757a385e,
  abstract     = {{<p>An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) as the unit of choice are not available for all traits of interest. The use of de-regressed proofs (DRPFs) of estimated breeding values (EBVs) is an alternative to using daughter yield deviations. The objective of this study was to examine possible differences between DYDs and DRPFs within the use of QTL detection. The pedigree used was part of the granddaughter design of the German QTL effort. Consisting marker maps for livestock species were derived from all available data of 16 German Holstein paternal half-sib families with a total of 872 sires. The number of progeny ranged from 19 to 127. A whole genome scan was performed using weighted and unweighted multimarker regression with DYDs, DRPFs and EBVs as dependent variables for the traits milk, fat and protein yields. Results were compared with respect to the number of QTL detected. A similar number of QTL was detected with DRPFs and DYDs. Also, when dependent variables were weighted according to the variance of the trait, a higher number of QTL was detected at the desired level of significance as compared to using unweighted variables.</p>}},
  author       = {{Thomsen, H. and Reinsch, N. and Xu, N. and Looft, C. and Grupe, S. and Kühn, C. and Brockmann, G. A. and Schwerin, M. and Leyhe-Horn, B. and Hiendleder, S. and Erhardt, G. and Medjugorac, I. and Russ, I. and Förster, M. and Brenig, B. and Reinhardt, F. and Reents, R. and Blümel, J. and Averdunk, G. and Kalm, E.}},
  issn         = {{0931-2668}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{6}},
  pages        = {{357--370}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Animal Breeding and Genetics}},
  title        = {{Comparison of estimated breeding values, daughter yield deviations and de-regressed proofs within a whole genome scan for QTL}},
  url          = {{http://dx.doi.org/10.1046/j.1439-0388.2001.00302.x}},
  doi          = {{10.1046/j.1439-0388.2001.00302.x}},
  volume       = {{118}},
  year         = {{2001}},
}