Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Orosomucoid, carotid plaque, and incidence of stroke

Berntsson, John LU ; Östling, Gerd LU ; Persson, Margaretha LU orcid ; Smith, J. Gustav LU orcid ; Hedblad, Bo LU and Engström, Gunnar LU (2016) In Stroke: a journal of cerebral circulation 47(7). p.1858-1863
Abstract

Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were assessed in 4285 subjects (39.8% men; mean age 57.5±5.9 years) without cardiovascular disease, who participated in the Malmö Diet and Cancer Study, between 1991 and 1994. The right carotid artery was examined for plaque using B-mode ultrasound examination. Incidence of stroke was followed up during a median follow-up time of 17.7 years. Results -... (More)

Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were assessed in 4285 subjects (39.8% men; mean age 57.5±5.9 years) without cardiovascular disease, who participated in the Malmö Diet and Cancer Study, between 1991 and 1994. The right carotid artery was examined for plaque using B-mode ultrasound examination. Incidence of stroke was followed up during a median follow-up time of 17.7 years. Results - Carotid plaque was present in 43.5% at baseline. Orosomucoid was significantly higher in subjects with carotid plaque (mean±SD: 0.72±0.22 versus 0.69±0.20 g/L; P

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute-phase reaction, carotid artery disease, cytokines, risk factor, stroke
in
Stroke: a journal of cerebral circulation
volume
47
issue
7
pages
6 pages
publisher
American Heart Association
external identifiers
  • pmid:27301938
  • wos:000379844900041
  • scopus:84974807325
ISSN
0039-2499
DOI
10.1161/STROKEAHA.116.013374
language
English
LU publication?
yes
id
30ab59ce-d947-4e92-8076-a6a24445beac
date added to LUP
2016-07-11 15:54:50
date last changed
2025-10-19 18:11:27
@article{30ab59ce-d947-4e92-8076-a6a24445beac,
  abstract     = {{<p>Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were assessed in 4285 subjects (39.8% men; mean age 57.5±5.9 years) without cardiovascular disease, who participated in the Malmö Diet and Cancer Study, between 1991 and 1994. The right carotid artery was examined for plaque using B-mode ultrasound examination. Incidence of stroke was followed up during a median follow-up time of 17.7 years. Results - Carotid plaque was present in 43.5% at baseline. Orosomucoid was significantly higher in subjects with carotid plaque (mean±SD: 0.72±0.22 versus 0.69±0.20 g/L; P</p>}},
  author       = {{Berntsson, John and Östling, Gerd and Persson, Margaretha and Smith, J. Gustav and Hedblad, Bo and Engström, Gunnar}},
  issn         = {{0039-2499}},
  keywords     = {{acute-phase reaction; carotid artery disease; cytokines; risk factor; stroke}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{1858--1863}},
  publisher    = {{American Heart Association}},
  series       = {{Stroke: a journal of cerebral circulation}},
  title        = {{Orosomucoid, carotid plaque, and incidence of stroke}},
  url          = {{http://dx.doi.org/10.1161/STROKEAHA.116.013374}},
  doi          = {{10.1161/STROKEAHA.116.013374}},
  volume       = {{47}},
  year         = {{2016}},
}