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Effect of food intake on biomarkers measured by the Proseek Multiplex Metabolism panel

Dencker, Magnus LU ; Björgell, Ola LU and Hlebowicz, Joanna LU (2026) In Clinical Physiology and Functional Imaging 46(3).
Abstract

Food intake induces metabolic and hemodynamic changes, but its impact on many circulating protein biomarkers remains unclear. This study assessed the effect of a standardised meal on 85 plasma biomarkers measured by the Proseek Multiplex Metabolism panel. Twenty-two healthy adults (11 men, 11 women; mean age 25.9  ±  4.2 years) were examined after an overnight fast and at 30 and 120 min following a standardised meal. Plasma samples were analysed with the Proseek Multiplex Metabolism panel. Twelve biomarkers decreased significantly after food intake; none increased. Eight biomarkers were reduced at 30 min, and four remained decreased at 120 min. The largest changes (>20%) were observed for DNA-(apurinic/apyrimidinic site)... (More)

Food intake induces metabolic and hemodynamic changes, but its impact on many circulating protein biomarkers remains unclear. This study assessed the effect of a standardised meal on 85 plasma biomarkers measured by the Proseek Multiplex Metabolism panel. Twenty-two healthy adults (11 men, 11 women; mean age 25.9  ±  4.2 years) were examined after an overnight fast and at 30 and 120 min following a standardised meal. Plasma samples were analysed with the Proseek Multiplex Metabolism panel. Twelve biomarkers decreased significantly after food intake; none increased. Eight biomarkers were reduced at 30 min, and four remained decreased at 120 min. The largest changes (>20%) were observed for DNA-(apurinic/apyrimidinic site) endonuclease, eosinophil cationic protein, thyrotropin subunit beta, carbonic anhydrase 13, and Crk-like protein. Food intake has modest effects on most biomarkers in the Proseek Multiplex Metabolism panel, suggesting fasting may not be critical for routine use. However, caution is warranted for biomarkers showing >20% change. Further studies in diverse populations and disease states are needed to confirm these findings.

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type
Contribution to journal
publication status
published
subject
keywords
Humans, Biomarkers/blood, Male, Female, Adult, Eating, Young Adult, Time Factors, Fasting/blood, Predictive Value of Tests, Healthy Volunteers, Blood Proteins/metabolism
in
Clinical Physiology and Functional Imaging
volume
46
issue
3
article number
e70069
publisher
Wiley-Blackwell
external identifiers
  • pmid:42145186
ISSN
1475-0961
DOI
10.1111/cpf.70069
language
English
LU publication?
yes
additional info
© 2026 Scandinavian Society of Clinical Physiology and Nuclear Medicine.
id
30c3332c-9217-4569-995c-7a1ba09a10f2
date added to LUP
2026-05-18 12:51:10
date last changed
2026-05-18 12:51:10
@article{30c3332c-9217-4569-995c-7a1ba09a10f2,
  abstract     = {{<p>Food intake induces metabolic and hemodynamic changes, but its impact on many circulating protein biomarkers remains unclear. This study assessed the effect of a standardised meal on 85 plasma biomarkers measured by the Proseek Multiplex Metabolism panel. Twenty-two healthy adults (11 men, 11 women; mean age 25.9  ±  4.2 years) were examined after an overnight fast and at 30 and 120 min following a standardised meal. Plasma samples were analysed with the Proseek Multiplex Metabolism panel. Twelve biomarkers decreased significantly after food intake; none increased. Eight biomarkers were reduced at 30 min, and four remained decreased at 120 min. The largest changes (&gt;20%) were observed for DNA-(apurinic/apyrimidinic site) endonuclease, eosinophil cationic protein, thyrotropin subunit beta, carbonic anhydrase 13, and Crk-like protein. Food intake has modest effects on most biomarkers in the Proseek Multiplex Metabolism panel, suggesting fasting may not be critical for routine use. However, caution is warranted for biomarkers showing &gt;20% change. Further studies in diverse populations and disease states are needed to confirm these findings.</p>}},
  author       = {{Dencker, Magnus and Björgell, Ola and Hlebowicz, Joanna}},
  issn         = {{1475-0961}},
  keywords     = {{Humans; Biomarkers/blood; Male; Female; Adult; Eating; Young Adult; Time Factors; Fasting/blood; Predictive Value of Tests; Healthy Volunteers; Blood Proteins/metabolism}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Physiology and Functional Imaging}},
  title        = {{Effect of food intake on biomarkers measured by the Proseek Multiplex Metabolism panel}},
  url          = {{http://dx.doi.org/10.1111/cpf.70069}},
  doi          = {{10.1111/cpf.70069}},
  volume       = {{46}},
  year         = {{2026}},
}