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Successful treatment of fulminant hepatitis B and fulminant hepatitis B and D coinfection explained by inhibitory effect on the immune response?

Hansson, B. G. LU ; Riesbeck, K. LU orcid ; Nordenfelt, E. and Weiland, O. (1991) In Progress in Clinical and Biological Research 364. p.421-427
Abstract

Foscarnet has been shown to inhibit the proliferation of human T and B lymphocytes in vitro. The production of lymphokines was more strongly affected than the DNA synthesis. Monocyte function was only partly inhibited by the highest foscarnet concentration tried. The influence of foscarnet on the immune system could explain the beneficial effect observed in patients with HBV-related fulminant hepatitis treated with foscarnet.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Clinical and Biological Research
volume
364
pages
421 - 427
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:1826956
  • scopus:0025983029
ISSN
0361-7742
language
English
LU publication?
yes
id
311f2e2c-8781-4d8d-a483-4327b6cfd416
date added to LUP
2019-03-27 14:27:47
date last changed
2024-01-01 00:27:27
@article{311f2e2c-8781-4d8d-a483-4327b6cfd416,
  abstract     = {{<p>Foscarnet has been shown to inhibit the proliferation of human T and B lymphocytes in vitro. The production of lymphokines was more strongly affected than the DNA synthesis. Monocyte function was only partly inhibited by the highest foscarnet concentration tried. The influence of foscarnet on the immune system could explain the beneficial effect observed in patients with HBV-related fulminant hepatitis treated with foscarnet.</p>}},
  author       = {{Hansson, B. G. and Riesbeck, K. and Nordenfelt, E. and Weiland, O.}},
  issn         = {{0361-7742}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{421--427}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Progress in Clinical and Biological Research}},
  title        = {{Successful treatment of fulminant hepatitis B and fulminant hepatitis B and D coinfection explained by inhibitory effect on the immune response?}},
  volume       = {{364}},
  year         = {{1991}},
}