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Prospective study of adult mental disturbance in offspring of women with psychosis

Schubert, Erland LU and McNeil, Thomas LU (2003) In Archives of General Psychiatry 60(5). p.473-480
Abstract
Background: The high-risk method is an important strategy for studying the antecedents and causes of schizophrenia and other psychoses'. The Swedish High-Risk Project is a prospective longitudinal study of offspring of women with a history of schizophrenic, schizoaffective, affective, or unspecified functional psychoses and control women with no history of psychosis. The offspring and their environments were studied beginning before birth, and again during,childhood. This article reports the mental outcome results from the first adult follow-up at age 22 years. Methods: Of 178 offspring, 166 (93%) were followed up and blindly assessed using standardized methods, including a self-report scale for mental symptoms and the Structured Clinical... (More)
Background: The high-risk method is an important strategy for studying the antecedents and causes of schizophrenia and other psychoses'. The Swedish High-Risk Project is a prospective longitudinal study of offspring of women with a history of schizophrenic, schizoaffective, affective, or unspecified functional psychoses and control women with no history of psychosis. The offspring and their environments were studied beginning before birth, and again during,childhood. This article reports the mental outcome results from the first adult follow-up at age 22 years. Methods: Of 178 offspring, 166 (93%) were followed up and blindly assessed using standardized methods, including a self-report scale for mental symptoms and the Structured Clinical Interview for DSM-III-R. Results: Compared with controls (n = 91), the offspring of mothers with schizophrenia (n = 28) showed a significantly increased frequency of DSM-III-R Axis I and Axis II disorders, poor global functioning, high Symptom Checklist-90 scores, and a history of mental, health care and psychopharmacologic medication use. Offspring of mothers with affective disorders (n = 22) showed high Symptom Checklist-90 scores, more frequent poor functioning, and receipt of mental health care, with a significant increase in Axis I depressive disorders and no increase in Axis II disorders. The extension of schizophrenia and affective risk groups to include additional maternal "spectrum cases" (10 and 15 individuals, respectively) generally yielded similar results. Conclusions: Maternal schizophrenia is associated with widespread increases in offspring mental disturbance in adolescence and young adulthood, differing from offspring disturbance associated with maternal affective disorder. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of General Psychiatry
volume
60
issue
5
pages
473 - 480
publisher
American Medical Association
external identifiers
  • wos:000182735000005
  • pmid:12742868
  • scopus:0038643576
ISSN
0003-990X
language
English
LU publication?
yes
id
99939be7-e539-458e-856d-2b4c251336ac (old id 312290)
alternative location
http://archpsyc.ama-assn.org/cgi/content/abstract/60/5/473
date added to LUP
2007-09-21 11:56:27
date last changed
2018-01-07 06:07:55
@article{99939be7-e539-458e-856d-2b4c251336ac,
  abstract     = {Background: The high-risk method is an important strategy for studying the antecedents and causes of schizophrenia and other psychoses'. The Swedish High-Risk Project is a prospective longitudinal study of offspring of women with a history of schizophrenic, schizoaffective, affective, or unspecified functional psychoses and control women with no history of psychosis. The offspring and their environments were studied beginning before birth, and again during,childhood. This article reports the mental outcome results from the first adult follow-up at age 22 years. Methods: Of 178 offspring, 166 (93%) were followed up and blindly assessed using standardized methods, including a self-report scale for mental symptoms and the Structured Clinical Interview for DSM-III-R. Results: Compared with controls (n = 91), the offspring of mothers with schizophrenia (n = 28) showed a significantly increased frequency of DSM-III-R Axis I and Axis II disorders, poor global functioning, high Symptom Checklist-90 scores, and a history of mental, health care and psychopharmacologic medication use. Offspring of mothers with affective disorders (n = 22) showed high Symptom Checklist-90 scores, more frequent poor functioning, and receipt of mental health care, with a significant increase in Axis I depressive disorders and no increase in Axis II disorders. The extension of schizophrenia and affective risk groups to include additional maternal "spectrum cases" (10 and 15 individuals, respectively) generally yielded similar results. Conclusions: Maternal schizophrenia is associated with widespread increases in offspring mental disturbance in adolescence and young adulthood, differing from offspring disturbance associated with maternal affective disorder.},
  author       = {Schubert, Erland and McNeil, Thomas},
  issn         = {0003-990X},
  language     = {eng},
  number       = {5},
  pages        = {473--480},
  publisher    = {American Medical Association},
  series       = {Archives of General Psychiatry},
  title        = {Prospective study of adult mental disturbance in offspring of women with psychosis},
  volume       = {60},
  year         = {2003},
}