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On-line monitoring of airborne chemistry in levitated nanodroplets: In situ synthesis and application of SERS-active Ag-sols for trace analysis by FT-Raman spectroscopy

Leopold, N; Haberkorn, M; Laurell, Thomas LU ; Nilsson, Johan LU ; Baena, JR; Frank, J and Lendl, B (2003) In Analytical Chemistry 75(9). p.2166-2171
Abstract
We report a new strategy for on-fine monitoring of chemical reactions in ultrasonically levitated, nanoliter-sized droplets by Raman spectroscopy. A flow-through microdispenser connected to an automated flow injection system was used to dose picoliter droplets into the node of an ultrasonic trap. Taking advantage of the flow-through characteristics of the microdispenser and the versatility of the automated flow system, a well-defined sequence of reagents could be injected via the microdispenser into the levitated droplet placed in the focus of the collection optics of the Fourier transform Raman spectrometer. In that way, chemical reactions could be carried out and monitored on-line. The developed system was used for fast, reproducible, in... (More)
We report a new strategy for on-fine monitoring of chemical reactions in ultrasonically levitated, nanoliter-sized droplets by Raman spectroscopy. A flow-through microdispenser connected to an automated flow injection system was used to dose picoliter droplets into the node of an ultrasonic trap. Taking advantage of the flow-through characteristics of the microdispenser and the versatility of the automated flow system, a well-defined sequence of reagents could be injected via the microdispenser into the levitated droplet placed in the focus of the collection optics of the Fourier transform Raman spectrometer. In that way, chemical reactions could be carried out and monitored on-line. The developed system was used for fast, reproducible, in situ synthesis of a highly active surface enhanced Raman scattering (SERS) sol resulting from the reduction of silver nitrate with hydroxylamine hydrochloride in basic conditions. With this chemical system, SERS substrate preparation could be achieved at room temperature and in short time. The in situ prepared silver sol was used for trace analysis of several organic test molecules that were injected into the levitated SERS-active droplet again using the microdispenser. The concentration dependence of the SERS spectra was studied using 9-aminoacridine, revealing that down to the femtogram region high-quality SERS spectra could be obtained. Additionally, SERS spectra of 6-mercaptopurine, thiamine, and acridine were recorded in the levitated drop as well. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
75
issue
9
pages
2166 - 2171
publisher
The American Chemical Society
external identifiers
  • wos:000182662800042
  • pmid:12720357
  • scopus:0038709687
ISSN
1520-6882
DOI
10.1021/ac026308l
language
English
LU publication?
yes
id
04dbed45-fa75-4315-aa83-77749ff239e5 (old id 312316)
date added to LUP
2007-09-16 12:05:09
date last changed
2018-10-03 10:22:01
@article{04dbed45-fa75-4315-aa83-77749ff239e5,
  abstract     = {We report a new strategy for on-fine monitoring of chemical reactions in ultrasonically levitated, nanoliter-sized droplets by Raman spectroscopy. A flow-through microdispenser connected to an automated flow injection system was used to dose picoliter droplets into the node of an ultrasonic trap. Taking advantage of the flow-through characteristics of the microdispenser and the versatility of the automated flow system, a well-defined sequence of reagents could be injected via the microdispenser into the levitated droplet placed in the focus of the collection optics of the Fourier transform Raman spectrometer. In that way, chemical reactions could be carried out and monitored on-line. The developed system was used for fast, reproducible, in situ synthesis of a highly active surface enhanced Raman scattering (SERS) sol resulting from the reduction of silver nitrate with hydroxylamine hydrochloride in basic conditions. With this chemical system, SERS substrate preparation could be achieved at room temperature and in short time. The in situ prepared silver sol was used for trace analysis of several organic test molecules that were injected into the levitated SERS-active droplet again using the microdispenser. The concentration dependence of the SERS spectra was studied using 9-aminoacridine, revealing that down to the femtogram region high-quality SERS spectra could be obtained. Additionally, SERS spectra of 6-mercaptopurine, thiamine, and acridine were recorded in the levitated drop as well.},
  author       = {Leopold, N and Haberkorn, M and Laurell, Thomas and Nilsson, Johan and Baena, JR and Frank, J and Lendl, B},
  issn         = {1520-6882},
  language     = {eng},
  number       = {9},
  pages        = {2166--2171},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {On-line monitoring of airborne chemistry in levitated nanodroplets: In situ synthesis and application of SERS-active Ag-sols for trace analysis by FT-Raman spectroscopy},
  url          = {http://dx.doi.org/10.1021/ac026308l},
  volume       = {75},
  year         = {2003},
}