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Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?

Nagorny, Cecilia LU and Lyssenko, Valeriya LU (2012) In Current Diabetes Reports 12(6). p.667-672
Abstract
Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor... (More)
Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor and its signaling pathways in respect to glucose homeostasis and development of the disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Diabetes Reports
volume
12
issue
6
pages
667 - 672
publisher
Current Science inc.
external identifiers
  • wos:000310706500005
  • pmid:23015324
  • scopus:84870710555
ISSN
1539-0829
DOI
10.1007/s11892-012-0327-y
language
English
LU publication?
yes
id
4ce263e5-e6c2-4454-acd9-e037c241807d (old id 3123619)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23015324?dopt=Abstract
date added to LUP
2012-10-03 21:07:15
date last changed
2017-11-12 04:06:01
@article{4ce263e5-e6c2-4454-acd9-e037c241807d,
  abstract     = {Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor and its signaling pathways in respect to glucose homeostasis and development of the disease.},
  author       = {Nagorny, Cecilia and Lyssenko, Valeriya},
  issn         = {1539-0829},
  language     = {eng},
  number       = {6},
  pages        = {667--672},
  publisher    = {Current Science inc.},
  series       = {Current Diabetes Reports},
  title        = {Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?},
  url          = {http://dx.doi.org/10.1007/s11892-012-0327-y},
  volume       = {12},
  year         = {2012},
}