Advanced

Islet nerves in focus-defining their neurobiological and clinical role.

Ahrén, Bo LU (2012) In Diabetologia
Abstract
Although it is well established that the pancreatic islets are innervated by autonomic nerves, the detailed islet innervation pattern is still unclear. In this issue of Diabetologia (DOI: 10.1007/s00125-012-2699-6 ) novel details of the islet neuroanatomy and its plasticity in experimental diabetes are described. By using a 3-dimensional (3-D) imaging technique, it has been shown that, in islets from normal mice, sympathetic nerves mainly form a neurovascular complex in addition to innervating peripherally located islet alpha cells. There are also pronounced changes in islet neuroanatomy in experimental diabetes. These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes,... (More)
Although it is well established that the pancreatic islets are innervated by autonomic nerves, the detailed islet innervation pattern is still unclear. In this issue of Diabetologia (DOI: 10.1007/s00125-012-2699-6 ) novel details of the islet neuroanatomy and its plasticity in experimental diabetes are described. By using a 3-dimensional (3-D) imaging technique, it has been shown that, in islets from normal mice, sympathetic nerves mainly form a neurovascular complex in addition to innervating peripherally located islet alpha cells. There are also pronounced changes in islet neuroanatomy in experimental diabetes. These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes, and therefore advance both basic and clinical knowledge of islet neurobiology. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
publisher
Springer Verlag
external identifiers
  • wos:000310381800002
  • pmid:23001378
  • scopus:84868203040
ISSN
1432-0428
DOI
10.1007/s00125-012-2727-6
language
English
LU publication?
yes
id
4b310acf-d9d8-4691-9c2d-c008f8e84bde (old id 3123744)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23001378?dopt=Abstract
date added to LUP
2012-10-03 22:48:17
date last changed
2017-01-01 07:32:24
@article{4b310acf-d9d8-4691-9c2d-c008f8e84bde,
  abstract     = {Although it is well established that the pancreatic islets are innervated by autonomic nerves, the detailed islet innervation pattern is still unclear. In this issue of Diabetologia (DOI: 10.1007/s00125-012-2699-6 ) novel details of the islet neuroanatomy and its plasticity in experimental diabetes are described. By using a 3-dimensional (3-D) imaging technique, it has been shown that, in islets from normal mice, sympathetic nerves mainly form a neurovascular complex in addition to innervating peripherally located islet alpha cells. There are also pronounced changes in islet neuroanatomy in experimental diabetes. These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes, and therefore advance both basic and clinical knowledge of islet neurobiology.},
  author       = {Ahrén, Bo},
  issn         = {1432-0428},
  language     = {eng},
  month        = {09},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Islet nerves in focus-defining their neurobiological and clinical role.},
  url          = {http://dx.doi.org/10.1007/s00125-012-2727-6},
  year         = {2012},
}