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The volume-expanding effects of autologous liquid stored plasma following hemorrhage.

Bentzer, Peter LU ; Thomas, Owain LU ; Westborg, Johan; Johansson, Pär I and Schött, Ulf LU (2012) In Scandinavian Journal of Clinical and Laboratory Investigation 72(6). p.490-494
Abstract
Background:

Plasma use has increased since studies have suggested that early treatment with blood components in trauma with severe hemorrhage may improve outcome. Plasma is also commonly used to correct coagulation disturbances in non-bleeding patients. Little is known about the effects of plasma transfusion on plasma volume. We report a prospective interventional study in which the plasma volume-expanding effect of autologous plasma was investigated after a controlled hemorrhage.



Methods:

Plasma obtained by plasmapheresis from nine healthy regular blood donors was stored at 2-6°C. Five weeks after donation the subjects were bled of 600 ml and then transfused with 600 ml of autologous plasma. Plasma... (More)
Background:

Plasma use has increased since studies have suggested that early treatment with blood components in trauma with severe hemorrhage may improve outcome. Plasma is also commonly used to correct coagulation disturbances in non-bleeding patients. Little is known about the effects of plasma transfusion on plasma volume. We report a prospective interventional study in which the plasma volume-expanding effect of autologous plasma was investigated after a controlled hemorrhage.



Methods:

Plasma obtained by plasmapheresis from nine healthy regular blood donors was stored at 2-6°C. Five weeks after donation the subjects were bled of 600 ml and then transfused with 600 ml of autologous plasma. Plasma volume was estimated using (125)I-albumin before and after bleeding, and immediately after plasma transfusion. Plasma volume changes were then estimated by measuring changes in hematocrit during the following 3-h period.



Results: Estimated plasma volume after bleeding was 3170 ± 320 ml and 3690 ± 380 ml (mean ± standard deviation) immediately following the transfusion of plasma (p 0.05). This increase in plasma volume corresponds to 86 ± 13% of the infused volume. Three hours after transfusion, plasma volume was still 3680 ± 410 ml.



Conclusions: Stored liquid plasma has a plasma volume expanding effect up to 86% of its infused volume with a duration of at least 3 h. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
72
issue
6
pages
490 - 494
publisher
Informa Healthcare
external identifiers
  • wos:000308941400009
  • pmid:22974297
  • scopus:84866352514
ISSN
1502-7686
DOI
10.3109/00365513.2012.699099
language
English
LU publication?
yes
id
02a07a7a-0903-4ff0-b8cb-cd4d1b089ce2 (old id 3123978)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22974297?dopt=Abstract
date added to LUP
2012-10-03 21:28:31
date last changed
2017-03-12 03:53:08
@article{02a07a7a-0903-4ff0-b8cb-cd4d1b089ce2,
  abstract     = {Background:<br/><br>
Plasma use has increased since studies have suggested that early treatment with blood components in trauma with severe hemorrhage may improve outcome. Plasma is also commonly used to correct coagulation disturbances in non-bleeding patients. Little is known about the effects of plasma transfusion on plasma volume. We report a prospective interventional study in which the plasma volume-expanding effect of autologous plasma was investigated after a controlled hemorrhage. <br/><br>
<br/><br>
Methods:<br/><br>
Plasma obtained by plasmapheresis from nine healthy regular blood donors was stored at 2-6°C. Five weeks after donation the subjects were bled of 600 ml and then transfused with 600 ml of autologous plasma. Plasma volume was estimated using (125)I-albumin before and after bleeding, and immediately after plasma transfusion. Plasma volume changes were then estimated by measuring changes in hematocrit during the following 3-h period. <br/><br>
<br/><br>
Results: Estimated plasma volume after bleeding was 3170 ± 320 ml and 3690 ± 380 ml (mean ± standard deviation) immediately following the transfusion of plasma (p 0.05). This increase in plasma volume corresponds to 86 ± 13% of the infused volume. Three hours after transfusion, plasma volume was still 3680 ± 410 ml. <br/><br>
<br/><br>
Conclusions: Stored liquid plasma has a plasma volume expanding effect up to 86% of its infused volume with a duration of at least 3 h.},
  author       = {Bentzer, Peter and Thomas, Owain and Westborg, Johan and Johansson, Pär I and Schött, Ulf},
  issn         = {1502-7686},
  language     = {eng},
  number       = {6},
  pages        = {490--494},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical and Laboratory Investigation},
  title        = {The volume-expanding effects of autologous liquid stored plasma following hemorrhage.},
  url          = {http://dx.doi.org/10.3109/00365513.2012.699099},
  volume       = {72},
  year         = {2012},
}