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Mortality and morbidity in adult craniopharyngioma.

Erfurth, Eva Marie LU ; Holmer, Helene and Fjalldal, Sigridur Bara (2013) In Pituitary 16. p.46-55
Abstract
A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised... (More)
A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised overall mortality rate varies 2.88-9.28 in cohort studies. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pituitary
volume
16
pages
46 - 55
publisher
Springer
external identifiers
  • wos:000314752100006
  • pmid:22961634
  • scopus:84873746680
  • pmid:22961634
ISSN
1573-7403
DOI
10.1007/s11102-012-0428-2
language
English
LU publication?
yes
id
c7de2cf3-f8f6-4cae-b740-2d5c0f6ff1a3 (old id 3124097)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22961634?dopt=Abstract
date added to LUP
2016-04-04 07:10:32
date last changed
2024-02-10 19:01:20
@article{c7de2cf3-f8f6-4cae-b740-2d5c0f6ff1a3,
  abstract     = {{A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised overall mortality rate varies 2.88-9.28 in cohort studies. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk.}},
  author       = {{Erfurth, Eva Marie and Holmer, Helene and Fjalldal, Sigridur Bara}},
  issn         = {{1573-7403}},
  language     = {{eng}},
  pages        = {{46--55}},
  publisher    = {{Springer}},
  series       = {{Pituitary}},
  title        = {{Mortality and morbidity in adult craniopharyngioma.}},
  url          = {{http://dx.doi.org/10.1007/s11102-012-0428-2}},
  doi          = {{10.1007/s11102-012-0428-2}},
  volume       = {{16}},
  year         = {{2013}},
}