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Mortality and morbidity in adult craniopharyngioma.

Erfurth, Eva Marie LU ; Holmer, Helene and Fjalldal, Sigridur Bara (2012) In Pituitary
Abstract
A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised... (More)
A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised overall mortality rate varies 2.88-9.28 in cohort studies. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. (Less)
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Contribution to journal
publication status
published
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Pituitary
publisher
Springer
external identifiers
  • wos:000314752100006
  • pmid:22961634
  • scopus:84873746680
ISSN
1573-7403
DOI
10.1007/s11102-012-0428-2
language
English
LU publication?
yes
id
c7de2cf3-f8f6-4cae-b740-2d5c0f6ff1a3 (old id 3124097)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22961634?dopt=Abstract
date added to LUP
2012-10-04 16:56:44
date last changed
2017-11-19 04:16:29
@article{c7de2cf3-f8f6-4cae-b740-2d5c0f6ff1a3,
  abstract     = {A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised overall mortality rate varies 2.88-9.28 in cohort studies. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk.},
  author       = {Erfurth, Eva Marie and Holmer, Helene and Fjalldal, Sigridur Bara},
  issn         = {1573-7403},
  language     = {eng},
  month        = {09},
  publisher    = {Springer},
  series       = {Pituitary},
  title        = {Mortality and morbidity in adult craniopharyngioma.},
  url          = {http://dx.doi.org/10.1007/s11102-012-0428-2},
  year         = {2012},
}