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Moraxella catarrhalis: from interactions with the host immune system to vaccine development.

Su, Yu-Ching; Singh, Birendra LU and Riesbeck, Kristian LU (2012) In Future Microbiology 7(9). p.1073-1100
Abstract
Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against... (More)
Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against complement killing and host bactericidal molecules. Thus, breaking the basis of Moraxella immune evasion mechanisms is fundamental for future invention of effective therapy in controlling Moraxella infection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Future Microbiology
volume
7
issue
9
pages
1073 - 1100
publisher
Future Medicine Ltd.
external identifiers
  • wos:000308255500009
  • pmid:22953708
  • scopus:84866069938
ISSN
1746-0921
DOI
10.2217/fmb.12.80
language
English
LU publication?
yes
id
1509e778-5680-484d-b68c-27eb0a551631 (old id 3124241)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22953708?dopt=Abstract
date added to LUP
2012-10-04 15:23:14
date last changed
2017-11-05 04:41:30
@article{1509e778-5680-484d-b68c-27eb0a551631,
  abstract     = {Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against complement killing and host bactericidal molecules. Thus, breaking the basis of Moraxella immune evasion mechanisms is fundamental for future invention of effective therapy in controlling Moraxella infection.},
  author       = {Su, Yu-Ching and Singh, Birendra and Riesbeck, Kristian},
  issn         = {1746-0921},
  language     = {eng},
  number       = {9},
  pages        = {1073--1100},
  publisher    = {Future Medicine Ltd.},
  series       = {Future Microbiology},
  title        = {Moraxella catarrhalis: from interactions with the host immune system to vaccine development.},
  url          = {http://dx.doi.org/10.2217/fmb.12.80},
  volume       = {7},
  year         = {2012},
}