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Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.

Cao, Lei LU ; Zhang, Yaping LU ; Cao, Yong-Xiao; Edvinsson, Lars LU and Xu, Cang-Bao LU (2012) In PLoS ONE 7(8).
Abstract
Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
7
issue
8
publisher
Public Library of Science
external identifiers
  • wos:000308044800100
  • pmid:22952915
  • scopus:84865437694
ISSN
1932-6203
DOI
10.1371/journal.pone.0044170
language
English
LU publication?
yes
id
733304be-b795-4682-8916-cd1774ecdcab (old id 3124252)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22952915?dopt=Abstract
date added to LUP
2012-10-04 15:37:33
date last changed
2017-07-09 03:50:05
@article{733304be-b795-4682-8916-cd1774ecdcab,
  abstract     = {Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.},
  articleno    = {e44170},
  author       = {Cao, Lei and Zhang, Yaping and Cao, Yong-Xiao and Edvinsson, Lars and Xu, Cang-Bao},
  issn         = {1932-6203},
  language     = {eng},
  number       = {8},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0044170},
  volume       = {7},
  year         = {2012},
}