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Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

Adler, Belinda LU ; Laurell, Thomas LU and Ekström, Simon LU (2012) In Electrophoresis 33(21). p.3143-3150
Abstract
The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Electrophoresis
volume
33
issue
21
pages
3143 - 3150
publisher
John Wiley & Sons
external identifiers
  • pmid:22949121
  • wos:000310476600004
  • scopus:84868014084
ISSN
0173-0835
DOI
10.1002/elps.201200134
project
CREATE Health
language
English
LU publication?
yes
id
418495ae-6941-4363-8a9e-9fa6c88a6662 (old id 3124345)
date added to LUP
2012-10-09 12:38:16
date last changed
2017-01-01 04:07:33
@article{418495ae-6941-4363-8a9e-9fa6c88a6662,
  abstract     = {The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.},
  author       = {Adler, Belinda and Laurell, Thomas and Ekström, Simon},
  issn         = {0173-0835},
  language     = {eng},
  number       = {21},
  pages        = {3143--3150},
  publisher    = {John Wiley & Sons},
  series       = {Electrophoresis},
  title        = {Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.},
  url          = {http://dx.doi.org/10.1002/elps.201200134},
  volume       = {33},
  year         = {2012},
}