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Effects of thermal degradation products from polyurethane foams based on toluene diisocyanate and diphenylmethane diisocyanate on isolated, perfused lung of guinea pig

Lastbom, L; Colmsjo, A; Johansson, R; Karlsson, Daniel LU ; Melin, J; Nordqvist, Y and Skarping, Gunnar LU (2003) In Scandinavian Journal of Work, Environment and Health 29(2). p.152-158
Abstract
Objectives The composition of thermal degradation products from two types of polyurethane foams, one based on toluene diisocyanate (TDI) and the other on diphenylmethane diisocyanate (MDI), was analyzed and their toxic lung effects were compared. Methods Isolated perfused lungs of guinea pig were subjected to thermal decomposition products of polyurethane foams from an aerosol generator with compartments for diluting, mixing, and sampling. Results Thermal degradation of MDI-based polyurethane foams released MDI, phenyl isocyanate, and methyl isocyanate. The emitted particulate fraction was 75% for MDI, whereas that for TDI from TDI-based polyurethane foam was 3%. Thermal degradation products from MDI-based foam caused a pronounced... (More)
Objectives The composition of thermal degradation products from two types of polyurethane foams, one based on toluene diisocyanate (TDI) and the other on diphenylmethane diisocyanate (MDI), was analyzed and their toxic lung effects were compared. Methods Isolated perfused lungs of guinea pig were subjected to thermal decomposition products of polyurethane foams from an aerosol generator with compartments for diluting, mixing, and sampling. Results Thermal degradation of MDI-based polyurethane foams released MDI, phenyl isocyanate, and methyl isocyanate. The emitted particulate fraction was 75% for MDI, whereas that for TDI from TDI-based polyurethane foam was 3%. Thermal degradation products from MDI-based foam caused a pronounced dose-dependent decrease in the measured lung function parameters (conductance and compliance). In contrast, the thermal degradation products from TDI-based foam did not cause any decrease in lung function. Conclusions Thermal degradation products generated from MDI-based polyurethane foam were more toxic to the lung than those generated from TDI-based polyurethane foam. This difference was probable due to MDI in the particle phase. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
phenyl isocyanate, mineral wool, aerosol, methyl isocyanate
in
Scandinavian Journal of Work, Environment and Health
volume
29
issue
2
pages
152 - 158
publisher
Finnish Institute of Occupational Health
external identifiers
  • pmid:12718501
  • wos:000182038500010
  • scopus:0242668732
ISSN
0355-3140
language
English
LU publication?
yes
id
89add9b0-ccd0-4ba6-acf9-6af2922195d6 (old id 313903)
alternative location
http://www.sjweh.fi/show_abstract.php?abstract_id=717
date added to LUP
2007-09-16 11:41:43
date last changed
2018-06-17 03:45:51
@article{89add9b0-ccd0-4ba6-acf9-6af2922195d6,
  abstract     = {Objectives The composition of thermal degradation products from two types of polyurethane foams, one based on toluene diisocyanate (TDI) and the other on diphenylmethane diisocyanate (MDI), was analyzed and their toxic lung effects were compared. Methods Isolated perfused lungs of guinea pig were subjected to thermal decomposition products of polyurethane foams from an aerosol generator with compartments for diluting, mixing, and sampling. Results Thermal degradation of MDI-based polyurethane foams released MDI, phenyl isocyanate, and methyl isocyanate. The emitted particulate fraction was 75% for MDI, whereas that for TDI from TDI-based polyurethane foam was 3%. Thermal degradation products from MDI-based foam caused a pronounced dose-dependent decrease in the measured lung function parameters (conductance and compliance). In contrast, the thermal degradation products from TDI-based foam did not cause any decrease in lung function. Conclusions Thermal degradation products generated from MDI-based polyurethane foam were more toxic to the lung than those generated from TDI-based polyurethane foam. This difference was probable due to MDI in the particle phase.},
  author       = {Lastbom, L and Colmsjo, A and Johansson, R and Karlsson, Daniel and Melin, J and Nordqvist, Y and Skarping, Gunnar},
  issn         = {0355-3140},
  keyword      = {phenyl isocyanate,mineral wool,aerosol,methyl isocyanate},
  language     = {eng},
  number       = {2},
  pages        = {152--158},
  publisher    = {Finnish Institute of Occupational Health},
  series       = {Scandinavian Journal of Work, Environment and Health},
  title        = {Effects of thermal degradation products from polyurethane foams based on toluene diisocyanate and diphenylmethane diisocyanate on isolated, perfused lung of guinea pig},
  volume       = {29},
  year         = {2003},
}