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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris, Andrew P.; Voight, Benjamin F.; Teslovich, Tanya M.; Ferreira, Teresa; Segre, Ayellet V.; Steinthorsdottir, Valgerdur; Strawbridge, Rona J.; Khan, Hassan; Grallert, Harald and Mahajan, Anubha, et al. (2012) In Nature Genetics 44(9). p.981-981
Abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
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Nature Genetics
volume
44
issue
9
pages
981 - 981
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Nature Publishing Group
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  • wos:000308491200009
  • scopus:84868337361
ISSN
1546-1718
DOI
10.1038/ng.2383
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English
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2012-11-01 11:05:34
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@article{b8fc18e7-0d89-439a-a0b3-792ec43d5bd6,
  abstract     = {To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.},
  author       = {Morris, Andrew P. and Voight, Benjamin F. and Teslovich, Tanya M. and Ferreira, Teresa and Segre, Ayellet V. and Steinthorsdottir, Valgerdur and Strawbridge, Rona J. and Khan, Hassan and Grallert, Harald and Mahajan, Anubha and Prokopenko, Inga and Kang, Hyun Min and Dina, Christian and Esko, Tonu and Fraser, Ross M. and Kanoni, Stavroula and Kumar, Ashish and Lagou, Vasiliki and Langenberg, Claudia and Luan, Jian'an and Lindgren, Cecilia M. and Mueller-Nurasyid, Martina and Pechlivanis, Sonali and Rayner, N. William and Scott, Laura J. and Wiltshire, Steven and Yengo, Loic and Kinnunen, Leena and Rossin, Elizabeth J. and Raychaudhuri, Soumya and Johnson, Andrew D. and Dimas, Antigone S. and Loos, Ruth J. F. and Vedantam, Sailaja and Chen, Han and Florez, Jose C. and Fox, Caroline and Liu, Ching-Ti and Rybin, Denis and Couper, David J. and Kao, Wen Hong L. and Li, Man and Cornelis, Marilyn C. and Kraft, Peter and Sun, Qi and van Dam, Rob M. and Stringham, Heather M. and Chines, Peter S. and Fischer, Krista and Fontanillas, Pierre and Holmen, Oddgeir L. and Hunt, Sarah E. and Jackson, Anne U. and Kong, Augustine and Lawrence, Robert and Meyer, Julia and Perry, John R. B. and Platou, Carl G. P. and Potter, Simon and Rehnberg, Emil and Robertson, Neil and Sivapalaratnam, Suthesh and Stancakova, Alena and Stirrups, Kathleen and Thorleifsson, Gudmar and Tikkanen, Emmi and Wood, Andrew R. and Almgren, Peter and Atalay, Mustafa and Benediktsson, Rafn and Bonnycastle, Lori L. and Burtt, Noel and Carey, Jason and Charpentier, Guillaume and Crenshaw, Andrew T. and Doney, Alex S. F. and Dorkhan, Mozhgan and Edkins, Sarah and Emilsson, Valur and Eury, Elodie and Forsen, Tom and Gertow, Karl and Gigante, Bruna and Grant, George B. and Groves, Christopher J. and Guiducci, Candace and Herder, Christian and Hreidarsson, Astradur B. and Hui, Jennie and James, Alan and Jonsson, Anna and Rathmann, Wolfgang and Klopp, Norman and Kravic, Jasmina and Krjutskov, Kaarel and Langford, Cordelia and Leander, Karin and Lindholm, Eero and Lobbens, Stephane and Mannisto, Satu and Mirza, Ghazala and Muehleisen, Thomas W. and Musk, Bill and Parkin, Melissa and Rallidis, Loukianos and Saramies, Jouko and Sennblad, Bengt and Shah, Sonia and Sigurdsson, Gunnar and Silveira, Angela and Steinbach, Gerald and Thorand, Barbara and Trakalo, Joseph and Veglia, Fabrizio and Wennauer, Roman and Winckler, Wendy and Zabaneh, Delilah and Campbell, Harry and van Duijn, Cornelia and Uitterlinden, Andre G. and Hofman, Albert and Sijbrands, Eric and Abecasis, Goncalo R. and Owen, Katharine R. and Zeggini, Eleftheria and Trip, Mieke D. and Forouhi, Nita G. and Syvanen, Ann-Christine and Eriksson, Johan G. and Peltonen, Leena and Noethen, Markus M. and Balkau, Beverley and Palmer, Colin N. A. and Lyssenko, Valeriya and Tuomi, Tiinamaija and Isomaa, Bo and Hunter, David J. and Qi, Lu and Shuldiner, Alan R. and Roden, Michael and Barroso, Ines and Wilsgaard, Tom and Beilby, John and Hovingh, Kees and Price, Jackie F. and Wilson, James F. and Rauramaa, Rainer and Lakka, Timo A. and Lind, Lars and Dedoussis, George and Njolstad, Inger and Pedersen, Nancy L. and Khaw, Kay-Tee and Wareham, Nicholas J. and Keinanen-Kiukaanniemi, Sirkka M. and Saaristo, Timo E. and Korpi-Hyovalti, Eeva and Saltevo, Juha and Laakso, Markku and Kuusisto, Johanna and Metspalu, Andres and Collins, Francis S. and Mohlke, Karen L. and Bergman, Richard N. and Tuomilehto, Jaakko and Boehm, Bernhard O. and Gieger, Christian and Hveem, Kristian and Cauchi, Stephane and Froguel, Philippe and Baldassarre, Damiano and Tremoli, Elena and Humphries, Steve E. and Saleheen, Danish and Danesh, John and Ingelsson, Erik and Ripatti, Samuli and Salomaa, Veikko and Erbel, Raimund and Joeckel, Karl-Heinz and Moebus, Susanne and Peters, Annette and Illig, Thomas and de Faire, Ulf and Hamsten, Anders and Morris, Andrew D. and Donnelly, Peter J. and Frayling, Timothy M. and Hattersley, Andrew T. and Boerwinkle, Eric and Melander, Olle and Kathiresan, Sekar and Nilsson, Peter and Deloukas, Panos and Thorsteinsdottir, Unnur and Groop, Leif and Stefansson, Kari and Hu, Frank and Pankow, James S. and Dupuis, Josee and Meigs, James B. and Altshuler, David and Boehnke, Michael and McCarthy, Mark I.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {9},
  pages        = {981--981},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes},
  url          = {http://dx.doi.org/10.1038/ng.2383},
  volume       = {44},
  year         = {2012},
}