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Lymphocytes in atherosclerosis

Wigren, Maria LU ; Nilsson, Jan LU and Kolbus, Daniel LU (2012) In Clinica Chimica Acta 413(19-20). p.1562-1568
Abstract
It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL. The immune system is challenged to determine whether these antigens should be regarded self and tolerated or non-self and eliminated. The latter will result in plaque development while the first will be protective. T cells are key effectors of both types of responses. An activation of regulatory T cells inhibits auto-reactive T effector cells and is anti-inflammatory. In contrast, if Th1 cells become activated... (More)
It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL. The immune system is challenged to determine whether these antigens should be regarded self and tolerated or non-self and eliminated. The latter will result in plaque development while the first will be protective. T cells are key effectors of both types of responses. An activation of regulatory T cells inhibits auto-reactive T effector cells and is anti-inflammatory. In contrast, if Th1 cells become activated in the plaque this is associated with increased inflammation and disease progression. The role of B cells in atherosclerosis remains to be clarified but some species of athero-protective antibodies have been identified. The elucidation of role of immune system in atherosclerosis has revealed new targets for intervention and both vaccines and antibody-based therapies are presently in or due to enter clinical testing. (c) 2012 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, Adaptive immunity, Regulatory T cells, Th1 cells, Immune therapy
in
Clinica Chimica Acta
volume
413
issue
19-20
pages
1562 - 1568
publisher
Elsevier
external identifiers
  • wos:000307924000026
  • scopus:84864391537
ISSN
0009-8981
DOI
10.1016/j.cca.2012.04.031
language
English
LU publication?
yes
id
1f8e5ff3-a7dd-45d5-a56e-d0ebc5f0d748 (old id 3147479)
date added to LUP
2012-11-01 09:38:21
date last changed
2017-10-01 03:22:15
@article{1f8e5ff3-a7dd-45d5-a56e-d0ebc5f0d748,
  abstract     = {It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL. The immune system is challenged to determine whether these antigens should be regarded self and tolerated or non-self and eliminated. The latter will result in plaque development while the first will be protective. T cells are key effectors of both types of responses. An activation of regulatory T cells inhibits auto-reactive T effector cells and is anti-inflammatory. In contrast, if Th1 cells become activated in the plaque this is associated with increased inflammation and disease progression. The role of B cells in atherosclerosis remains to be clarified but some species of athero-protective antibodies have been identified. The elucidation of role of immune system in atherosclerosis has revealed new targets for intervention and both vaccines and antibody-based therapies are presently in or due to enter clinical testing. (c) 2012 Elsevier B.V. All rights reserved.},
  author       = {Wigren, Maria and Nilsson, Jan and Kolbus, Daniel},
  issn         = {0009-8981},
  keyword      = {Atherosclerosis,Adaptive immunity,Regulatory T cells,Th1 cells,Immune therapy},
  language     = {eng},
  number       = {19-20},
  pages        = {1562--1568},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Lymphocytes in atherosclerosis},
  url          = {http://dx.doi.org/10.1016/j.cca.2012.04.031},
  volume       = {413},
  year         = {2012},
}