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Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization

Zhang, XY; Dong, X; Zheng, L; Luo, GH; Liu, YH; Ekström, Ulf LU ; Nilsson-Ehle, Peter LU ; Ye, Q and Xu, Ning LU (2003) In Acta Histochemica 105(1). p.67-72
Abstract
Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human... (More)
Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human kidney. The present study helps to elucidate the pathophysiological functions of apoM in vivo. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
in situ hybridization, kidney, liver, apolipoprotein M
in
Acta Histochemica
volume
105
issue
1
pages
67 - 72
publisher
Elsevier
external identifiers
  • wos:000181692500006
  • pmid:12666989
  • scopus:0037219269
ISSN
0065-1281
DOI
language
English
LU publication?
yes
id
56241ed6-6289-410a-8240-118f1fb98bbf (old id 315611)
date added to LUP
2007-09-24 15:42:40
date last changed
2018-05-29 10:28:01
@article{56241ed6-6289-410a-8240-118f1fb98bbf,
  abstract     = {Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human kidney. The present study helps to elucidate the pathophysiological functions of apoM in vivo.},
  author       = {Zhang, XY and Dong, X and Zheng, L and Luo, GH and Liu, YH and Ekström, Ulf and Nilsson-Ehle, Peter and Ye, Q and Xu, Ning},
  issn         = {0065-1281},
  keyword      = {in situ hybridization,kidney,liver,apolipoprotein M},
  language     = {eng},
  number       = {1},
  pages        = {67--72},
  publisher    = {Elsevier},
  series       = {Acta Histochemica},
  title        = {Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization},
  url          = {http://dx.doi.org/},
  volume       = {105},
  year         = {2003},
}