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Platelet-dependent neutrophil function is dysregulated by M protein from Streptococcus pyogenes.

Hurley, Sinead LU ; Kahn, Fredrik LU ; Nordenfelt, Pontus LU orcid ; Mörgelin, Matthias LU ; Sørensen, Ole E LU and Shannon, Oonagh LU (2015) In Infection and Immunity 83(9). p.3515-3525
Abstract
Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Herein we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombin gave rise to platelet-dependent neutrophil activation, resulting in enhanced phagocytosis and bacterial killing. Streptococcus pyogenes is an important causative agent of severe infectious disease, which can manifest as sepsis and septic shock. M1 protein from S. pyogenes also mediated platelet-neutrophil complex formation, however these... (More)
Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Herein we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombin gave rise to platelet-dependent neutrophil activation, resulting in enhanced phagocytosis and bacterial killing. Streptococcus pyogenes is an important causative agent of severe infectious disease, which can manifest as sepsis and septic shock. M1 protein from S. pyogenes also mediated platelet-neutrophil complex formation, however these neutrophils were dysfunctional and exhibited diminished chemotactic ability and bacterial killing. This reveals an important agonist dependent neutrophil dysfunction during platelet-neutrophil complex formation, and highlights the role of platelets during the immune response to streptococcal infection. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
83
issue
9
pages
3515 - 3525
publisher
American Society for Microbiology
external identifiers
  • pmid:26099589
  • wos:000359435600017
  • scopus:84939500893
  • pmid:26099589
ISSN
1098-5522
DOI
10.1128/IAI.00508-15
language
English
LU publication?
yes
id
3157a858-651c-4bbc-b491-b2bd2535a284 (old id 7478500)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26099589?dopt=Abstract
date added to LUP
2016-04-01 09:58:15
date last changed
2022-04-12 00:41:30
@article{3157a858-651c-4bbc-b491-b2bd2535a284,
  abstract     = {{Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Herein we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombin gave rise to platelet-dependent neutrophil activation, resulting in enhanced phagocytosis and bacterial killing. Streptococcus pyogenes is an important causative agent of severe infectious disease, which can manifest as sepsis and septic shock. M1 protein from S. pyogenes also mediated platelet-neutrophil complex formation, however these neutrophils were dysfunctional and exhibited diminished chemotactic ability and bacterial killing. This reveals an important agonist dependent neutrophil dysfunction during platelet-neutrophil complex formation, and highlights the role of platelets during the immune response to streptococcal infection.}},
  author       = {{Hurley, Sinead and Kahn, Fredrik and Nordenfelt, Pontus and Mörgelin, Matthias and Sørensen, Ole E and Shannon, Oonagh}},
  issn         = {{1098-5522}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{3515--3525}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Infection and Immunity}},
  title        = {{Platelet-dependent neutrophil function is dysregulated by M protein from Streptococcus pyogenes.}},
  url          = {{http://dx.doi.org/10.1128/IAI.00508-15}},
  doi          = {{10.1128/IAI.00508-15}},
  volume       = {{83}},
  year         = {{2015}},
}