Multiple implants do not aggravate the tissue reaction in rat brain.
(2012) In PLoS ONE 7(10).- Abstract
- Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electrodes is not clear. We implanted multiple wire bundles into the brain of rats and studied the correlation between the astrocytic and microglial reaction and the positioning of the electrode in relation to surrounding electrodes. We found that an electrode implanted in the middle of a row of implants is surrounded by a significantly smaller... (More)
- Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electrodes is not clear. We implanted multiple wire bundles into the brain of rats and studied the correlation between the astrocytic and microglial reaction and the positioning of the electrode in relation to surrounding electrodes. We found that an electrode implanted in the middle of a row of implants is surrounded by a significantly smaller astrocytic scar than single ones. This possible interaction was only seen between implants within the same hemisphere, no interaction with the contralateral hemisphere was found. More importantly, we found no aggravation of tissue reactions as a result of a larger number of implants. These results highlight the possibility of implanting multiple electrodes without aggravating the glial scar surrounding each implant. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160455
- author
- Lind, Gustav LU ; Gällentoft, Lina LU ; Danielsen, Nils LU ; Schouenborg, Jens LU and Pettersson, Lina LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 7
- issue
- 10
- article number
- e47509
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000310135800052
- pmid:23091629
- scopus:84867617507
- pmid:23091629
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0047509
- project
- Vävnadsreaktioner i nervsystemet efter elektrodimplantation
- language
- English
- LU publication?
- yes
- id
- 3fa15ea7-0184-4d35-96e5-628dcb439627 (old id 3160455)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23091629?dopt=Abstract
- date added to LUP
- 2016-04-04 09:38:32
- date last changed
- 2024-01-12 16:20:40
@article{3fa15ea7-0184-4d35-96e5-628dcb439627,
abstract = {{Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electrodes is not clear. We implanted multiple wire bundles into the brain of rats and studied the correlation between the astrocytic and microglial reaction and the positioning of the electrode in relation to surrounding electrodes. We found that an electrode implanted in the middle of a row of implants is surrounded by a significantly smaller astrocytic scar than single ones. This possible interaction was only seen between implants within the same hemisphere, no interaction with the contralateral hemisphere was found. More importantly, we found no aggravation of tissue reactions as a result of a larger number of implants. These results highlight the possibility of implanting multiple electrodes without aggravating the glial scar surrounding each implant.}},
author = {{Lind, Gustav and Gällentoft, Lina and Danielsen, Nils and Schouenborg, Jens and Pettersson, Lina}},
issn = {{1932-6203}},
language = {{eng}},
number = {{10}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Multiple implants do not aggravate the tissue reaction in rat brain.}},
url = {{https://lup.lub.lu.se/search/files/5378587/3223772.pdf}},
doi = {{10.1371/journal.pone.0047509}},
volume = {{7}},
year = {{2012}},
}