Advanced

Multiple implants do not aggravate the tissue reaction in rat brain.

Lind, Gustav LU ; Gällentoft, Lina LU ; Danielsen, Nils LU ; Schouenborg, Jens LU and Pettersson, Lina LU (2012) In PLoS ONE 7(10).
Abstract
Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electrodes is not clear. We implanted multiple wire bundles into the brain of rats and studied the correlation between the astrocytic and microglial reaction and the positioning of the electrode in relation to surrounding electrodes. We found that an electrode implanted in the middle of a row of implants is surrounded by a significantly smaller... (More)
Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electrodes is not clear. We implanted multiple wire bundles into the brain of rats and studied the correlation between the astrocytic and microglial reaction and the positioning of the electrode in relation to surrounding electrodes. We found that an electrode implanted in the middle of a row of implants is surrounded by a significantly smaller astrocytic scar than single ones. This possible interaction was only seen between implants within the same hemisphere, no interaction with the contralateral hemisphere was found. More importantly, we found no aggravation of tissue reactions as a result of a larger number of implants. These results highlight the possibility of implanting multiple electrodes without aggravating the glial scar surrounding each implant. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
7
issue
10
publisher
Public Library of Science
external identifiers
  • wos:000310135800052
  • pmid:23091629
  • scopus:84867617507
ISSN
1932-6203
DOI
10.1371/journal.pone.0047509
language
English
LU publication?
yes
id
3fa15ea7-0184-4d35-96e5-628dcb439627 (old id 3160455)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23091629?dopt=Abstract
date added to LUP
2012-11-01 12:50:17
date last changed
2017-10-08 04:36:09
@article{3fa15ea7-0184-4d35-96e5-628dcb439627,
  abstract     = {Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electrodes is not clear. We implanted multiple wire bundles into the brain of rats and studied the correlation between the astrocytic and microglial reaction and the positioning of the electrode in relation to surrounding electrodes. We found that an electrode implanted in the middle of a row of implants is surrounded by a significantly smaller astrocytic scar than single ones. This possible interaction was only seen between implants within the same hemisphere, no interaction with the contralateral hemisphere was found. More importantly, we found no aggravation of tissue reactions as a result of a larger number of implants. These results highlight the possibility of implanting multiple electrodes without aggravating the glial scar surrounding each implant.},
  articleno    = {e47509},
  author       = {Lind, Gustav and Gällentoft, Lina and Danielsen, Nils and Schouenborg, Jens and Pettersson, Lina},
  issn         = {1932-6203},
  language     = {eng},
  number       = {10},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Multiple implants do not aggravate the tissue reaction in rat brain.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0047509},
  volume       = {7},
  year         = {2012},
}