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Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora.

Johansson, Daniel LU and Rasmussen, Magnus LU (2012) In Microbial Pathogenesis
Abstract
Infective endocarditis (IE) is a severe infection associated with significant morbidity and mortality. Enterococcus faecalis is among the most common causes of this disease, and yet little is known about the pathogenesis of E. faecalis IE. We screened 21 E. faecalis isolates from IE and 21 isolates from normal flora for the putative virulence factors ace, asa1, gelE, and esp with PCR. In addition, we determined the ability of the isolates to form biofilm and to aggregate platelets. With the exception of biofilm formation, which was more pronounced in the normal flora group, there was no difference between the groups, indicating that many isolates have virulence properties and that host factors might determine if E. faecalis causes IE.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbial Pathogenesis
publisher
Academic Press
external identifiers
  • wos:000314444600005
  • pmid:23044056
  • scopus:84876125225
ISSN
1096-1208
DOI
10.1016/j.micpath.2012.09.009
language
English
LU publication?
yes
id
85ccb45c-fb2c-4fd6-bdc1-713388978ec4 (old id 3160996)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23044056?dopt=Abstract
date added to LUP
2012-11-01 15:16:45
date last changed
2017-10-22 04:55:37
@article{85ccb45c-fb2c-4fd6-bdc1-713388978ec4,
  abstract     = {Infective endocarditis (IE) is a severe infection associated with significant morbidity and mortality. Enterococcus faecalis is among the most common causes of this disease, and yet little is known about the pathogenesis of E. faecalis IE. We screened 21 E. faecalis isolates from IE and 21 isolates from normal flora for the putative virulence factors ace, asa1, gelE, and esp with PCR. In addition, we determined the ability of the isolates to form biofilm and to aggregate platelets. With the exception of biofilm formation, which was more pronounced in the normal flora group, there was no difference between the groups, indicating that many isolates have virulence properties and that host factors might determine if E. faecalis causes IE.},
  author       = {Johansson, Daniel and Rasmussen, Magnus},
  issn         = {1096-1208},
  language     = {eng},
  month        = {10},
  publisher    = {Academic Press},
  series       = {Microbial Pathogenesis},
  title        = {Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora.},
  url          = {http://dx.doi.org/10.1016/j.micpath.2012.09.009},
  year         = {2012},
}