Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora.
(2012) In Microbial Pathogenesis- Abstract
- Infective endocarditis (IE) is a severe infection associated with significant morbidity and mortality. Enterococcus faecalis is among the most common causes of this disease, and yet little is known about the pathogenesis of E. faecalis IE. We screened 21 E. faecalis isolates from IE and 21 isolates from normal flora for the putative virulence factors ace, asa1, gelE, and esp with PCR. In addition, we determined the ability of the isolates to form biofilm and to aggregate platelets. With the exception of biofilm formation, which was more pronounced in the normal flora group, there was no difference between the groups, indicating that many isolates have virulence properties and that host factors might determine if E. faecalis causes IE.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160996
- author
- Johansson, Daniel LU and Rasmussen, Magnus LU
- organization
- publishing date
- 2012-10-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Microbial Pathogenesis
- publisher
- Academic Press
- external identifiers
-
- wos:000314444600005
- pmid:23044056
- scopus:84876125225
- pmid:23044056
- ISSN
- 1096-1208
- DOI
- 10.1016/j.micpath.2012.09.009
- language
- English
- LU publication?
- yes
- id
- 85ccb45c-fb2c-4fd6-bdc1-713388978ec4 (old id 3160996)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23044056?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:11
- date last changed
- 2022-01-29 07:34:10
@article{85ccb45c-fb2c-4fd6-bdc1-713388978ec4, abstract = {{Infective endocarditis (IE) is a severe infection associated with significant morbidity and mortality. Enterococcus faecalis is among the most common causes of this disease, and yet little is known about the pathogenesis of E. faecalis IE. We screened 21 E. faecalis isolates from IE and 21 isolates from normal flora for the putative virulence factors ace, asa1, gelE, and esp with PCR. In addition, we determined the ability of the isolates to form biofilm and to aggregate platelets. With the exception of biofilm formation, which was more pronounced in the normal flora group, there was no difference between the groups, indicating that many isolates have virulence properties and that host factors might determine if E. faecalis causes IE.}}, author = {{Johansson, Daniel and Rasmussen, Magnus}}, issn = {{1096-1208}}, language = {{eng}}, month = {{10}}, publisher = {{Academic Press}}, series = {{Microbial Pathogenesis}}, title = {{Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora.}}, url = {{http://dx.doi.org/10.1016/j.micpath.2012.09.009}}, doi = {{10.1016/j.micpath.2012.09.009}}, year = {{2012}}, }