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Multimodal management of colorectal liver metastases and the effect on regeneration and outcome after liver resection.

Ansari, Daniel LU ; Bergenfeldt, Magnus LU ; Tingstedt, Bobby LU and Andersson, Roland LU (2012) In Scandinavian Journal of Gastroenterology
Abstract
Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy. Sparing liver parenchyma in patients with bilobar liver metastatic disease subjected to liver resection may be possible without endangering surgical radicality. Sparing liver parenchyma when using neoadjuvant chemotherapy, a... (More)
Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy. Sparing liver parenchyma in patients with bilobar liver metastatic disease subjected to liver resection may be possible without endangering surgical radicality. Sparing liver parenchyma when using neoadjuvant chemotherapy, a chemotherapy-free period of 6 weeks or more seems to positively affect liver regeneration. There is still the possibility to reresect recurrent liver lesions, though there seems to be a tendency toward fewer reresections following the use of adjuvant chemotherapy. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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Scandinavian Journal of Gastroenterology
publisher
Taylor & Francis
external identifiers
  • WOS:000312427800008
  • PMID:23035803
  • Scopus:84870018867
ISSN
1502-7708
DOI
10.3109/00365521.2012.729083
language
English
LU publication?
yes
id
0c2680f7-fc94-42d6-9639-6c3f93cc331b (old id 3161119)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23035803?dopt=Abstract
date added to LUP
2012-11-01 13:11:03
date last changed
2017-01-01 07:51:46
@article{0c2680f7-fc94-42d6-9639-6c3f93cc331b,
  abstract     = {Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy. Sparing liver parenchyma in patients with bilobar liver metastatic disease subjected to liver resection may be possible without endangering surgical radicality. Sparing liver parenchyma when using neoadjuvant chemotherapy, a chemotherapy-free period of 6 weeks or more seems to positively affect liver regeneration. There is still the possibility to reresect recurrent liver lesions, though there seems to be a tendency toward fewer reresections following the use of adjuvant chemotherapy.},
  author       = {Ansari, Daniel and Bergenfeldt, Magnus and Tingstedt, Bobby and Andersson, Roland},
  issn         = {1502-7708},
  language     = {eng},
  month        = {10},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Multimodal management of colorectal liver metastases and the effect on regeneration and outcome after liver resection.},
  url          = {http://dx.doi.org/10.3109/00365521.2012.729083},
  year         = {2012},
}