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The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments

Magnusson, Patrik KE; Almqvist, Catarina; Rahma, Iffat; Ganna, Andrea; Viktorin, Alexander; Walum, Hasse; Halldner, Linda; Lundström, Sebastian; Ullén, Fredrik and Långström, Niklas, et al. (2012) In Twin Research and Human Genetics p.1-13
Abstract
The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these,

approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important

epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from... (More)
The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these,

approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important

epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples

as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described. (Less)
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Contribution to journal
publication status
published
subject
keywords
population-based, twin, registry, biobank, Sweden
in
Twin Research and Human Genetics
pages
1 - 13
publisher
Australian Academic Press
external identifiers
  • wos:000314799700048
  • scopus:84873917050
ISSN
1839-2628
DOI
10.1017/thg.2012.104
language
English
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yes
id
f585c9b4-0764-40e5-a6b3-6fa82f5de6b8 (old id 3168031)
date added to LUP
2012-11-14 14:39:14
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2017-10-22 03:02:17
@article{f585c9b4-0764-40e5-a6b3-6fa82f5de6b8,
  abstract     = {The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these,<br/><br>
approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important<br/><br>
epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples<br/><br>
as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.},
  author       = {Magnusson, Patrik KE and Almqvist, Catarina and Rahma, Iffat and Ganna, Andrea and Viktorin, Alexander and Walum, Hasse and Halldner, Linda and Lundström, Sebastian and Ullén, Fredrik and Långström, Niklas and Larsson, Henrik and Nyman, Anastasia and Hellner Gumpert, Clara and Råstam, Maria and Anckarsäter, Henrik and Cnattingius, Sven and Johannesson, Magnus and Ingelsson, Erik and Klareskog, Lars and de Faire, Ulf and Pedersen, Nancy L and Lichtenstein, Paul},
  issn         = {1839-2628},
  keyword      = {population-based,twin,registry,biobank,Sweden},
  language     = {eng},
  pages        = {1--13},
  publisher    = {Australian Academic Press},
  series       = {Twin Research and Human Genetics},
  title        = {The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments},
  url          = {http://dx.doi.org/10.1017/thg.2012.104},
  year         = {2012},
}