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3D absorbed dose calculations based on SPECT: Evaluation for 111-In/90-Y therapy using Monte Carlo simulations.

Ljungberg, Michael LU ; Frey, E; Sjögreen Gleisner, Katarina LU ; Liu, XW; Dewaraja, Y and Strand, Sven-Erik LU (2003) In Cancer Biotherapy & Radiopharmaceuticals 18(1). p.99-107
Abstract
A general method is presented for patient-specific three-dimensional (3D) absorbed dose calculations based on quantitative SPECT activity measurements. The computational scheme includes a method for registration of the CT study to the SPECT image, and compensation for attenuation, scatter, and collimator-detector response including septal penetration, performed as part of an iterative reconstruction method. From SPECT images, the absorbed dose rate is calculated using an EGS4 Monte Carlo code, which converts the activity distribution to an absorbed dose rate distribution. Evaluation of the accuracy in the activity quantification and the absorbed dose calculation is based on realistic Monte Carlo simulated SPECT data of a voxel-computer... (More)
A general method is presented for patient-specific three-dimensional (3D) absorbed dose calculations based on quantitative SPECT activity measurements. The computational scheme includes a method for registration of the CT study to the SPECT image, and compensation for attenuation, scatter, and collimator-detector response including septal penetration, performed as part of an iterative reconstruction method. From SPECT images, the absorbed dose rate is calculated using an EGS4 Monte Carlo code, which converts the activity distribution to an absorbed dose rate distribution. Evaluation of the accuracy in the activity quantification and the absorbed dose calculation is based on realistic Monte Carlo simulated SPECT data of a voxel-computer phantom and In-111 and Y-90. Septal penetration was not included in this study. The SPECT-based activity concentrations and absorbed dose distributions are compared to the actual values; the results imply that the corrections for attenuation and scatter yield results of high accuracy. The presented method includes compensation for most parameters deteriorating the quantitative image information. Inaccuracies are, however, introduced by the limited spatial resolution of the SPECT system, which are not fully compensated by the collimator-response correction. The proposed evaluation methodology may be used as a basis for future inter-comparison of different dosimetry calculation schemes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
simulation, attenuation, scatter, quantification, SPECT, Monte Carlo, dosimetry
in
Cancer Biotherapy & Radiopharmaceuticals
volume
18
issue
1
pages
99 - 107
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000181441400011
  • pmid:12667313
  • scopus:0037222431
ISSN
1557-8852
DOI
10.1089/108497803321269377
language
English
LU publication?
yes
id
f74a9669-cd4a-4990-b12f-9acd4175de61 (old id 317036)
date added to LUP
2007-09-17 11:09:59
date last changed
2018-07-22 03:58:58
@article{f74a9669-cd4a-4990-b12f-9acd4175de61,
  abstract     = {A general method is presented for patient-specific three-dimensional (3D) absorbed dose calculations based on quantitative SPECT activity measurements. The computational scheme includes a method for registration of the CT study to the SPECT image, and compensation for attenuation, scatter, and collimator-detector response including septal penetration, performed as part of an iterative reconstruction method. From SPECT images, the absorbed dose rate is calculated using an EGS4 Monte Carlo code, which converts the activity distribution to an absorbed dose rate distribution. Evaluation of the accuracy in the activity quantification and the absorbed dose calculation is based on realistic Monte Carlo simulated SPECT data of a voxel-computer phantom and In-111 and Y-90. Septal penetration was not included in this study. The SPECT-based activity concentrations and absorbed dose distributions are compared to the actual values; the results imply that the corrections for attenuation and scatter yield results of high accuracy. The presented method includes compensation for most parameters deteriorating the quantitative image information. Inaccuracies are, however, introduced by the limited spatial resolution of the SPECT system, which are not fully compensated by the collimator-response correction. The proposed evaluation methodology may be used as a basis for future inter-comparison of different dosimetry calculation schemes.},
  author       = {Ljungberg, Michael and Frey, E and Sjögreen Gleisner, Katarina and Liu, XW and Dewaraja, Y and Strand, Sven-Erik},
  issn         = {1557-8852},
  keyword      = {simulation,attenuation,scatter,quantification,SPECT,Monte Carlo,dosimetry},
  language     = {eng},
  number       = {1},
  pages        = {99--107},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Cancer Biotherapy & Radiopharmaceuticals},
  title        = {3D absorbed dose calculations based on SPECT: Evaluation for 111-In/90-Y therapy using Monte Carlo simulations.},
  url          = {http://dx.doi.org/10.1089/108497803321269377},
  volume       = {18},
  year         = {2003},
}