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A 5-methylcoumarin glucoside and a coumestan derivative from Mutisia orbignyana.

Flores, Yonny LU ; Rodrigo, Gloria LU ; Mollinedo, Patricia; Åkesson, Björn LU ; Sterner, Olov LU and Almanza, Giovanna (2009) In Revista Boliviana de Química 26(1). p.21-26
Abstract
The ethanolic extract of the aerial parts from Mutisia orbignyana afforded two major compounds: mutisifurocoumarin (1) and 5-methylcoumarine-4-β-glucoside (2). The completely assignment of 1H and 13C NMR data of compound (2) is presented for the first time as well as some reassignments of 13C NMR spectrum for compound (1), applying 2D NMR techniques. In addition, the antiproliferative effect on colon cancer cells (CaCo2) and the scavenging effect using the ABTS test were measured The results showed an interesting scavenging activity and a non proliferative effect on colon cancer cells./El extracto etanólico de las partes aéreas de Mutisia orbignyana presentó dos compuestos mayoritarios: mutisifurocumarina (1) y... (More)
The ethanolic extract of the aerial parts from Mutisia orbignyana afforded two major compounds: mutisifurocoumarin (1) and 5-methylcoumarine-4-β-glucoside (2). The completely assignment of 1H and 13C NMR data of compound (2) is presented for the first time as well as some reassignments of 13C NMR spectrum for compound (1), applying 2D NMR techniques. In addition, the antiproliferative effect on colon cancer cells (CaCo2) and the scavenging effect using the ABTS test were measured The results showed an interesting scavenging activity and a non proliferative effect on colon cancer cells./El extracto etanólico de las partes aéreas de Mutisia orbignyana presentó dos compuestos mayoritarios: mutisifurocumarina (1) y 5-metilcumarina-4-β-glucosilada (2). El asignamiento completo de RMN de 1H y 13C del compuesto (2) es presentado por primera vez, así como también algunos reasignamientos del espectro de RMN13C del compuesto (1), en ambos casos se aplico técnicas de RMN 2D. Además, se midió el efecto antiproliferativo sobre células cancerosas de colon (CaCo2) y el efecto como inhibidores de radicales libres usando la prueba ABTS, tanto de extractos como de compuestos puros. Los resultados muestran un interesante efecto antiradicalario en ABTS y un efecto no-proliferativo sobre células cancerosas de colon. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Revista Boliviana de Química
volume
26
issue
1
pages
21 - 26
publisher
Universidad Mayor de San Andres, Instituto de Invertigaciones Químicas
ISSN
0250-5460
language
English
LU publication?
yes
id
71bb4305-5530-41f9-b1bc-efe396fc165d (old id 3173910)
date added to LUP
2012-11-23 13:07:24
date last changed
2016-04-16 00:41:46
@article{71bb4305-5530-41f9-b1bc-efe396fc165d,
  abstract     = {The ethanolic extract of the aerial parts from Mutisia orbignyana afforded two major compounds: mutisifurocoumarin (1) and 5-methylcoumarine-4-β-glucoside (2). The completely assignment of 1H and 13C NMR data of compound (2) is presented for the first time as well as some reassignments of 13C NMR spectrum for compound (1), applying 2D NMR techniques. In addition, the antiproliferative effect on colon cancer cells (CaCo2) and the scavenging effect using the ABTS test were measured The results showed an interesting scavenging activity and a non proliferative effect on colon cancer cells./El extracto etanólico de las partes aéreas de Mutisia orbignyana presentó dos compuestos mayoritarios: mutisifurocumarina (1) y 5-metilcumarina-4-β-glucosilada (2). El asignamiento completo de RMN de 1H y 13C del compuesto (2) es presentado por primera vez, así como también algunos reasignamientos del espectro de RMN13C del compuesto (1), en ambos casos se aplico técnicas de RMN 2D. Además, se midió el efecto antiproliferativo sobre células cancerosas de colon (CaCo2) y el efecto como inhibidores de radicales libres usando la prueba ABTS, tanto de extractos como de compuestos puros. Los resultados muestran un interesante efecto antiradicalario en ABTS y un efecto no-proliferativo sobre células cancerosas de colon.},
  author       = {Flores, Yonny and Rodrigo, Gloria and Mollinedo, Patricia and Åkesson, Björn and Sterner, Olov and Almanza, Giovanna},
  issn         = {0250-5460},
  language     = {eng},
  number       = {1},
  pages        = {21--26},
  publisher    = {Universidad Mayor de San Andres, Instituto de Invertigaciones Químicas},
  series       = {Revista Boliviana de Química},
  title        = {A 5-methylcoumarin glucoside and a coumestan derivative from Mutisia orbignyana.},
  volume       = {26},
  year         = {2009},
}