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5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete

Filip, P; Anke, T and Sterner, Olov LU (2002) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 57(11-12). p.1004-1008
Abstract
5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell JURKAT, the human hepatocellular carcinoma cell line HEP-G2 as well as the J774 mouse macrophage cell line. The compounds induce morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently die by apoptosis. Both compounds show no antibacterial and antifungal activity.
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organization
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Contribution to journal
publication status
published
subject
keywords
5-(2'-oxoheptadecyl)-resorcinol and 5-(2'-oxononadecyl)-resorcinol, basidiomycete, cytotoxic activities
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
57
issue
11-12
pages
1004 - 1008
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000181126300010
  • scopus:0036875770
ISSN
0939-5075
language
English
LU publication?
yes
id
979d1ca8-107c-406c-8cec-eb0143f9918a (old id 317446)
alternative location
http://www.znaturforsch.com/ac/v57c/s57c1004.pdf
date added to LUP
2007-08-17 12:47:16
date last changed
2017-03-05 04:03:32
@article{979d1ca8-107c-406c-8cec-eb0143f9918a,
  abstract     = {5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell JURKAT, the human hepatocellular carcinoma cell line HEP-G2 as well as the J774 mouse macrophage cell line. The compounds induce morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently die by apoptosis. Both compounds show no antibacterial and antifungal activity.},
  author       = {Filip, P and Anke, T and Sterner, Olov},
  issn         = {0939-5075},
  keyword      = {5-(2'-oxoheptadecyl)-resorcinol and 5-(2'-oxononadecyl)-resorcinol,basidiomycete,cytotoxic activities},
  language     = {eng},
  number       = {11-12},
  pages        = {1004--1008},
  publisher    = {Verlag der Zeitschrift für Naturforschung},
  series       = {Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences},
  title        = {5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete},
  volume       = {57},
  year         = {2002},
}