5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete
(2002) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 57(11-12). p.1004-1008- Abstract
- 5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell JURKAT, the human hepatocellular carcinoma cell line HEP-G2 as well as the J774 mouse macrophage cell line. The compounds induce morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently die by apoptosis. Both compounds show no antibacterial and antifungal activity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/317446
- author
- Filip, P ; Anke, T and Sterner, Olov LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 5-(2'-oxoheptadecyl)-resorcinol and 5-(2'-oxononadecyl)-resorcinol, basidiomycete, cytotoxic activities
- in
- Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
- volume
- 57
- issue
- 11-12
- pages
- 1004 - 1008
- publisher
- Verlag der Zeitschrift für Naturforschung
- external identifiers
-
- wos:000181126300010
- scopus:0036875770
- ISSN
- 0939-5075
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 979d1ca8-107c-406c-8cec-eb0143f9918a (old id 317446)
- alternative location
- http://www.znaturforsch.com/ac/v57c/s57c1004.pdf
- date added to LUP
- 2016-04-01 15:37:23
- date last changed
- 2022-01-28 06:16:32
@article{979d1ca8-107c-406c-8cec-eb0143f9918a, abstract = {{5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell JURKAT, the human hepatocellular carcinoma cell line HEP-G2 as well as the J774 mouse macrophage cell line. The compounds induce morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently die by apoptosis. Both compounds show no antibacterial and antifungal activity.}}, author = {{Filip, P and Anke, T and Sterner, Olov}}, issn = {{0939-5075}}, keywords = {{5-(2'-oxoheptadecyl)-resorcinol and 5-(2'-oxononadecyl)-resorcinol; basidiomycete; cytotoxic activities}}, language = {{eng}}, number = {{11-12}}, pages = {{1004--1008}}, publisher = {{Verlag der Zeitschrift für Naturforschung}}, series = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}}, title = {{5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete}}, url = {{http://www.znaturforsch.com/ac/v57c/s57c1004.pdf}}, volume = {{57}}, year = {{2002}}, }