NFAT regulation in smooth muscle
Hill-Eubanks, DC ; Gomez, Maria LU
; Stevenson, AS
and Nelson, MT
(2003)
In Trends in Cardiovascular Medicine
13(2).
p.56-62
- Abstract
- First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the... (More)
- First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the role of additional mechanisms that act to modulate calcineurin-dependent NFAT nuclear import/export, mechanisms that may have particular relevance in this tissue. (C) 2003, Elsevier Science Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/317994
- author
- Hill-Eubanks, DC
; Gomez, Maria
LU
; Stevenson, AS
and Nelson, MT
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Cardiovascular Medicine
- volume
- 13
- issue
- 2
- pages
- 56 - 62
- publisher
- Elsevier
- external identifiers
-
- pmid:12586440
- wos:000180950200003
- scopus:12244275742
- ISSN
- 1873-2615
- DOI
- 10.1016/S1050-1738(02)00212-8
- language
- English
- LU publication?
- yes
- id
- 45c54c39-ca2d-4645-be98-12189e7e9bd6 (old id 317994)
- date added to LUP
- 2016-04-01 11:42:31
- date last changed
- 2022-02-03 03:23:38
@article{45c54c39-ca2d-4645-be98-12189e7e9bd6,
abstract = {{First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the role of additional mechanisms that act to modulate calcineurin-dependent NFAT nuclear import/export, mechanisms that may have particular relevance in this tissue. (C) 2003, Elsevier Science Inc.}},
author = {{Hill-Eubanks, DC and Gomez, Maria and Stevenson, AS and Nelson, MT}},
issn = {{1873-2615}},
language = {{eng}},
number = {{2}},
pages = {{56--62}},
publisher = {{Elsevier}},
series = {{Trends in Cardiovascular Medicine}},
title = {{NFAT regulation in smooth muscle}},
url = {{http://dx.doi.org/10.1016/S1050-1738(02)00212-8}},
doi = {{10.1016/S1050-1738(02)00212-8}},
volume = {{13}},
year = {{2003}},
}