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NFAT regulation in smooth muscle

Hill-Eubanks, DC; Gomez, Maria LU ; Stevenson, AS and Nelson, MT (2003) In Trends in Cardiovascular Medicine 13(2). p.56-62
Abstract
First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the... (More)
First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the role of additional mechanisms that act to modulate calcineurin-dependent NFAT nuclear import/export, mechanisms that may have particular relevance in this tissue. (C) 2003, Elsevier Science Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Cardiovascular Medicine
volume
13
issue
2
pages
56 - 62
publisher
Elsevier
external identifiers
  • pmid:12586440
  • wos:000180950200003
  • scopus:12244275742
ISSN
1873-2615
DOI
language
English
LU publication?
yes
id
45c54c39-ca2d-4645-be98-12189e7e9bd6 (old id 317994)
date added to LUP
2007-09-13 09:52:42
date last changed
2018-05-29 09:22:27
@article{45c54c39-ca2d-4645-be98-12189e7e9bd6,
  abstract     = {First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the role of additional mechanisms that act to modulate calcineurin-dependent NFAT nuclear import/export, mechanisms that may have particular relevance in this tissue. (C) 2003, Elsevier Science Inc.},
  author       = {Hill-Eubanks, DC and Gomez, Maria and Stevenson, AS and Nelson, MT},
  issn         = {1873-2615},
  language     = {eng},
  number       = {2},
  pages        = {56--62},
  publisher    = {Elsevier},
  series       = {Trends in Cardiovascular Medicine},
  title        = {NFAT regulation in smooth muscle},
  url          = {http://dx.doi.org/},
  volume       = {13},
  year         = {2003},
}