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Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus

Ekelund, Magnus LU ; Shaat, Nael LU ; Almgren, Peter LU ; Anderberg, Eva LU ; Landin-Olsson, Mona LU ; Lyssenko, Valeriya LU ; Groop, Leif LU and Berntorp, Kerstin LU (2012) In Diabetes Research and Clinical Practice 97(3). p.394-398
Abstract
Aims: To examine whether genetic variants that predispose individuals to type 2 diabetes (T2D) could predict the development of diabetes after gestational diabetes mellitus (GDM). Methods: 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP2 rs1470579 and rs4402960, SLC30A8 rs13266634, TCF7L2 rs7903146, PPARG rs1801282, GCK rs1799884, HNF1A rs1169288, and KCNJ11 rs5219) were genotyped in 793 women with GDM after a median follow-up of 57 months. Results: After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants significantly predicted postpartum diabetes; hazard ratio (95% confidence interval 1.29 (1.01-1.66) and 1.36 (1.06-1.74), respectively (additive... (More)
Aims: To examine whether genetic variants that predispose individuals to type 2 diabetes (T2D) could predict the development of diabetes after gestational diabetes mellitus (GDM). Methods: 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP2 rs1470579 and rs4402960, SLC30A8 rs13266634, TCF7L2 rs7903146, PPARG rs1801282, GCK rs1799884, HNF1A rs1169288, and KCNJ11 rs5219) were genotyped in 793 women with GDM after a median follow-up of 57 months. Results: After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants significantly predicted postpartum diabetes; hazard ratio (95% confidence interval 1.29 (1.01-1.66) and 1.36 (1.06-1.74), respectively (additive model) versus 1.45 (1.01-2.08) and 1.56 (1.06-2.29) (dominant model)). Adjusting for BMI attenuated the effect of the FTO variant, suggesting that the effect was mediated through its effect on BMI. Combining all risk alleles to a weighted risk score was significantly associated with the risk of postpartum diabetes (hazard ratio 1.11, 95% confidence interval 1.05-1.18, p = 0.00016 after adjustment for age and ethnicity). Conclusions: The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D risk alleles, predict diabetes after GDM. Further studies in other populations are needed to confirm our results. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
FTO, Gestational diabetes mellitus (GDM), Postpartum diabetes, Risk, prediction, Risk score, TCF7L2
in
Diabetes Research and Clinical Practice
volume
97
issue
3
pages
394 - 398
publisher
Elsevier
external identifiers
  • wos:000309292100010
  • scopus:84866525534
ISSN
1872-8227
DOI
10.1016/j.diabres.2012.04.020
language
English
LU publication?
yes
id
d0efd2e4-836a-4732-aa06-e80626d5a686 (old id 3191266)
date added to LUP
2012-12-03 07:11:12
date last changed
2017-07-30 03:06:27
@article{d0efd2e4-836a-4732-aa06-e80626d5a686,
  abstract     = {Aims: To examine whether genetic variants that predispose individuals to type 2 diabetes (T2D) could predict the development of diabetes after gestational diabetes mellitus (GDM). Methods: 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP2 rs1470579 and rs4402960, SLC30A8 rs13266634, TCF7L2 rs7903146, PPARG rs1801282, GCK rs1799884, HNF1A rs1169288, and KCNJ11 rs5219) were genotyped in 793 women with GDM after a median follow-up of 57 months. Results: After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants significantly predicted postpartum diabetes; hazard ratio (95% confidence interval 1.29 (1.01-1.66) and 1.36 (1.06-1.74), respectively (additive model) versus 1.45 (1.01-2.08) and 1.56 (1.06-2.29) (dominant model)). Adjusting for BMI attenuated the effect of the FTO variant, suggesting that the effect was mediated through its effect on BMI. Combining all risk alleles to a weighted risk score was significantly associated with the risk of postpartum diabetes (hazard ratio 1.11, 95% confidence interval 1.05-1.18, p = 0.00016 after adjustment for age and ethnicity). Conclusions: The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D risk alleles, predict diabetes after GDM. Further studies in other populations are needed to confirm our results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Ekelund, Magnus and Shaat, Nael and Almgren, Peter and Anderberg, Eva and Landin-Olsson, Mona and Lyssenko, Valeriya and Groop, Leif and Berntorp, Kerstin},
  issn         = {1872-8227},
  keyword      = {FTO,Gestational diabetes mellitus (GDM),Postpartum diabetes,Risk,prediction,Risk score,TCF7L2},
  language     = {eng},
  number       = {3},
  pages        = {394--398},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus},
  url          = {http://dx.doi.org/10.1016/j.diabres.2012.04.020},
  volume       = {97},
  year         = {2012},
}