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High leptin levels are associated with stroke

Soderberg, S; Stegmayr, B; Ahlbeck-Glader, C; Slunga-Birgander, L; Ahrén, Bo LU and Olsson, T (2003) In Cerebrovascular Diseases 15(1-2). p.63-69
Abstract
Background and Purpose: Leptin, an important hormone for body weight regulation, may be involved in the pathogenesis of cardiovascular manifestations of obesity. We tested whether leptin may be an independent risk marker for stroke in a case-referent study. Methods: Definitive acute stroke events, defined by MONICA criteria, were identified from October 1, 1995 to April 30, 1999. Referents without known cardiovascular disease were randomly selected from a population census. Patient characteristics were taken from hospital files and leptin was analyzed in stored samples. Logistic regression analysis was used to determine possible differences in leptin levels between groups. Results: One hundred and thirty-seven cases with ischemic stroke... (More)
Background and Purpose: Leptin, an important hormone for body weight regulation, may be involved in the pathogenesis of cardiovascular manifestations of obesity. We tested whether leptin may be an independent risk marker for stroke in a case-referent study. Methods: Definitive acute stroke events, defined by MONICA criteria, were identified from October 1, 1995 to April 30, 1999. Referents without known cardiovascular disease were randomly selected from a population census. Patient characteristics were taken from hospital files and leptin was analyzed in stored samples. Logistic regression analysis was used to determine possible differences in leptin levels between groups. Results: One hundred and thirty-seven cases with ischemic stroke and 69 cases with hemorrhagic stroke were identified. In comparison with referents, male patients with stroke had significantly higher leptin levels. Both male and female stroke patients had increased blood pressure compared with the referents. In multivariate analyses, high leptin levels were associated with both ischemic (OR = 4.89; 95% CI: 1.89-12.62) and hemorrhagic (OR = 3.86; 95% CI: 1.13-13.16) stroke in men, and with ischemic stroke in women (OR = 4.10; 95% CI: 1.45-11.62). The combination of high leptin levels and increased blood pressure (systolic or diastolic) was associated with a strong positive interaction in males with hemorrhagic stroke. Conclusion: Leptin may be an important link for the development of cerebrovascular disease in the insulin resistance syndrome in men. Copyright (C) 2003 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
case-referent study, ischemic stroke, hemorrhagic stroke, stroke, leptin, risk factor
in
Cerebrovascular Diseases
volume
15
issue
1-2
pages
63 - 69
publisher
Karger
external identifiers
  • wos:000180575100011
  • scopus:0037242940
ISSN
1421-9786
DOI
language
English
LU publication?
yes
id
e027d65f-b7bf-4ee7-b50b-101ed014118b (old id 319610)
date added to LUP
2007-09-22 11:28:45
date last changed
2018-05-29 12:31:09
@article{e027d65f-b7bf-4ee7-b50b-101ed014118b,
  abstract     = {Background and Purpose: Leptin, an important hormone for body weight regulation, may be involved in the pathogenesis of cardiovascular manifestations of obesity. We tested whether leptin may be an independent risk marker for stroke in a case-referent study. Methods: Definitive acute stroke events, defined by MONICA criteria, were identified from October 1, 1995 to April 30, 1999. Referents without known cardiovascular disease were randomly selected from a population census. Patient characteristics were taken from hospital files and leptin was analyzed in stored samples. Logistic regression analysis was used to determine possible differences in leptin levels between groups. Results: One hundred and thirty-seven cases with ischemic stroke and 69 cases with hemorrhagic stroke were identified. In comparison with referents, male patients with stroke had significantly higher leptin levels. Both male and female stroke patients had increased blood pressure compared with the referents. In multivariate analyses, high leptin levels were associated with both ischemic (OR = 4.89; 95% CI: 1.89-12.62) and hemorrhagic (OR = 3.86; 95% CI: 1.13-13.16) stroke in men, and with ischemic stroke in women (OR = 4.10; 95% CI: 1.45-11.62). The combination of high leptin levels and increased blood pressure (systolic or diastolic) was associated with a strong positive interaction in males with hemorrhagic stroke. Conclusion: Leptin may be an important link for the development of cerebrovascular disease in the insulin resistance syndrome in men. Copyright (C) 2003 S. Karger AG, Basel.},
  author       = {Soderberg, S and Stegmayr, B and Ahlbeck-Glader, C and Slunga-Birgander, L and Ahrén, Bo and Olsson, T},
  issn         = {1421-9786},
  keyword      = {case-referent study,ischemic stroke,hemorrhagic stroke,stroke,leptin,risk factor},
  language     = {eng},
  number       = {1-2},
  pages        = {63--69},
  publisher    = {Karger},
  series       = {Cerebrovascular Diseases},
  title        = {High leptin levels are associated with stroke},
  url          = {http://dx.doi.org/},
  volume       = {15},
  year         = {2003},
}