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Clinical and histopathological features of malignant melanoma in germline CDKN2A mutation families

Måsbäck, Anna LU ; Olsson, Håkan LU ; Westerdahl, Johan LU ; Törngren, Therese LU ; Borg, Åke LU ; Jonsson, Nils LU and Ingvar, Christian LU (2002) In Melanoma Research 12(6). p.549-557
Abstract
Primary cutaneous malignant melanomas (CMMs) from 26 individuals belonging to nine families with an identified CDKN2A mutation were clinically and histopathologically compared with 78 matched CMM controls and with a population-based series of CMMs (n=667). All tumours were histopathologically re-examined. CDKN2A-associated cases were significantly less invasive compared with the matched controls, with an adjusted odds ratio (adjOR) of 2.9 and a 95% confidence interval (CI) of 1.0-8.1 (P=0.04). According to the odds ratio (OR) values, CDKN2A-associated cases seemed to have tumours more often located on the head and neck (adjOR 2.9, 95% CI 0.6-13.7), with less inflammation (adjOR 0.7, 95% CI 0.3-1.8) and regression (adjOR 0.6, 95% CI... (More)
Primary cutaneous malignant melanomas (CMMs) from 26 individuals belonging to nine families with an identified CDKN2A mutation were clinically and histopathologically compared with 78 matched CMM controls and with a population-based series of CMMs (n=667). All tumours were histopathologically re-examined. CDKN2A-associated cases were significantly less invasive compared with the matched controls, with an adjusted odds ratio (adjOR) of 2.9 and a 95% confidence interval (CI) of 1.0-8.1 (P=0.04). According to the odds ratio (OR) values, CDKN2A-associated cases seemed to have tumours more often located on the head and neck (adjOR 2.9, 95% CI 0.6-13.7), with less inflammation (adjOR 0.7, 95% CI 0.3-1.8) and regression (adjOR 0.6, 95% CI 0.2-1.8) but more frequent histological ulceration (adjOR 1.9, 95% CI 0.6-5.8). In comparison with the population-based material, CDKN2A-associated cases were significantly younger at diagnosis (crude OR 3.5, 95% CI 1.6-7.5, divided at 50 years) and had less regressive reaction in their tumours (crude OR 0.355 95% CI 0.2-0.8). No significant differences were seen for tumour thickness between the different groups. On multivariate analysis, the overall survival was significantly worse for thicker tumours and older age (P=0.04 for both). To our knowledge this is the first description of the histopathological features of CMMs from families with mutations in the CDKN2A gene. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
mutation, melanoma, histopathology, CDKN2A, hereditary, population-based
in
Melanoma Research
volume
12
issue
6
pages
549 - 557
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000180388100004
  • scopus:12244262260
ISSN
0960-8931
DOI
10.1097/01.cmr.0000043152.28051.18
language
English
LU publication?
yes
id
9bd69dbb-83b2-4aff-b40d-c5ba31b3631f (old id 319740)
alternative location
http://www.melanomaresearch.com/pt/re/melres/abstract.00008390-200212000-00004.htm;jsessionid=Hq5RQT2R78sLbLF5yb9WJn53pgH7RfFHyHJ17HK9ByrdCzd5w8Bv!-1947435345!181195628!8091!-1
date added to LUP
2007-11-02 11:21:03
date last changed
2017-03-26 03:40:39
@article{9bd69dbb-83b2-4aff-b40d-c5ba31b3631f,
  abstract     = {Primary cutaneous malignant melanomas (CMMs) from 26 individuals belonging to nine families with an identified CDKN2A mutation were clinically and histopathologically compared with 78 matched CMM controls and with a population-based series of CMMs (n=667). All tumours were histopathologically re-examined. CDKN2A-associated cases were significantly less invasive compared with the matched controls, with an adjusted odds ratio (adjOR) of 2.9 and a 95% confidence interval (CI) of 1.0-8.1 (P=0.04). According to the odds ratio (OR) values, CDKN2A-associated cases seemed to have tumours more often located on the head and neck (adjOR 2.9, 95% CI 0.6-13.7), with less inflammation (adjOR 0.7, 95% CI 0.3-1.8) and regression (adjOR 0.6, 95% CI 0.2-1.8) but more frequent histological ulceration (adjOR 1.9, 95% CI 0.6-5.8). In comparison with the population-based material, CDKN2A-associated cases were significantly younger at diagnosis (crude OR 3.5, 95% CI 1.6-7.5, divided at 50 years) and had less regressive reaction in their tumours (crude OR 0.355 95% CI 0.2-0.8). No significant differences were seen for tumour thickness between the different groups. On multivariate analysis, the overall survival was significantly worse for thicker tumours and older age (P=0.04 for both). To our knowledge this is the first description of the histopathological features of CMMs from families with mutations in the CDKN2A gene.},
  author       = {Måsbäck, Anna and Olsson, Håkan and Westerdahl, Johan and Törngren, Therese and Borg, Åke and Jonsson, Nils and Ingvar, Christian},
  issn         = {0960-8931},
  keyword      = {mutation,melanoma,histopathology,CDKN2A,hereditary,population-based},
  language     = {eng},
  number       = {6},
  pages        = {549--557},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Melanoma Research},
  title        = {Clinical and histopathological features of malignant melanoma in germline CDKN2A mutation families},
  url          = {http://dx.doi.org/10.1097/01.cmr.0000043152.28051.18},
  volume       = {12},
  year         = {2002},
}