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Sibling Alcohol Use Disorder Is Associated With Increased Risk for Suicide Attempt

Stephenson, Mallory E. ; Larsson Lönn, Sara LU ; Salvatore, Jessica E. ; Sundquist, Jan LU ; Kendler, Kenneth S. LU ; Sundquist, Kristina LU and Edwards, Alexis C. LU (2022) In Clinical Psychological Science 10(2). p.374-382
Abstract

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently... (More)

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol use disorder, environmental risk factor, sibling, suicidal behavior, suicide attempt
in
Clinical Psychological Science
volume
10
issue
2
pages
374 - 382
publisher
SAGE Publications
external identifiers
  • scopus:85108404047
  • pmid:35599838
ISSN
2167-7026
DOI
10.1177/21677026211025041
language
English
LU publication?
yes
id
31d05ac0-bf2e-4381-a745-2bcf0fdc2c83
date added to LUP
2022-03-08 11:14:17
date last changed
2024-04-14 03:22:39
@article{31d05ac0-bf2e-4381-a745-2bcf0fdc2c83,
  abstract     = {{<p>The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.</p>}},
  author       = {{Stephenson, Mallory E. and Larsson Lönn, Sara and Salvatore, Jessica E. and Sundquist, Jan and Kendler, Kenneth S. and Sundquist, Kristina and Edwards, Alexis C.}},
  issn         = {{2167-7026}},
  keywords     = {{alcohol use disorder; environmental risk factor; sibling; suicidal behavior; suicide attempt}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{374--382}},
  publisher    = {{SAGE Publications}},
  series       = {{Clinical Psychological Science}},
  title        = {{Sibling Alcohol Use Disorder Is Associated With Increased Risk for Suicide Attempt}},
  url          = {{http://dx.doi.org/10.1177/21677026211025041}},
  doi          = {{10.1177/21677026211025041}},
  volume       = {{10}},
  year         = {{2022}},
}