Sibling Alcohol Use Disorder Is Associated With Increased Risk for Suicide Attempt
(2022) In Clinical Psychological Science 10(2). p.374-382- Abstract
The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently... (More)
The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.
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- author
- Stephenson, Mallory E. ; Larsson Lönn, Sara LU ; Salvatore, Jessica E. ; Sundquist, Jan LU ; Kendler, Kenneth S. LU ; Sundquist, Kristina LU and Edwards, Alexis C. LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alcohol use disorder, environmental risk factor, sibling, suicidal behavior, suicide attempt
- in
- Clinical Psychological Science
- volume
- 10
- issue
- 2
- pages
- 374 - 382
- publisher
- SAGE Publications
- external identifiers
-
- scopus:85108404047
- pmid:35599838
- ISSN
- 2167-7026
- DOI
- 10.1177/21677026211025041
- language
- English
- LU publication?
- yes
- id
- 31d05ac0-bf2e-4381-a745-2bcf0fdc2c83
- date added to LUP
- 2022-03-08 11:14:17
- date last changed
- 2024-04-14 03:22:39
@article{31d05ac0-bf2e-4381-a745-2bcf0fdc2c83, abstract = {{<p>The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.</p>}}, author = {{Stephenson, Mallory E. and Larsson Lönn, Sara and Salvatore, Jessica E. and Sundquist, Jan and Kendler, Kenneth S. and Sundquist, Kristina and Edwards, Alexis C.}}, issn = {{2167-7026}}, keywords = {{alcohol use disorder; environmental risk factor; sibling; suicidal behavior; suicide attempt}}, language = {{eng}}, number = {{2}}, pages = {{374--382}}, publisher = {{SAGE Publications}}, series = {{Clinical Psychological Science}}, title = {{Sibling Alcohol Use Disorder Is Associated With Increased Risk for Suicide Attempt}}, url = {{http://dx.doi.org/10.1177/21677026211025041}}, doi = {{10.1177/21677026211025041}}, volume = {{10}}, year = {{2022}}, }