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New frontiers in lung transplantation : a bioengineering perspective

Lindstedt, Sandra LU ; Perch, Michael ; Meloni, Federica and Niroomand, Anna LU (2024) In ERS Monograph 2024. p.277-285
Abstract

LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine grafts, presents a promising solution. Additionally, the development of artificial lungs offers another avenue to address the shortage. Artificial lung devices, ranging from extracorporeal to implantable systems, aim to provide temporary or permanent respiratory support, potentially reducing the reliance on human donors. This chapter also... (More)

LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine grafts, presents a promising solution. Additionally, the development of artificial lungs offers another avenue to address the shortage. Artificial lung devices, ranging from extracorporeal to implantable systems, aim to provide temporary or permanent respiratory support, potentially reducing the reliance on human donors. This chapter also discusses the role of gene and cell therapies in enhancing the function and survival of transplanted lungs. Ex vivo lung perfusion platforms are highlighted for their utility in delivering these therapies, optimising graft condition before transplantation. The integration of these bioengineering innovations could significantly impact the future of LTx, offering new lifelines to patients in need.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Lung Transplantation
series title
ERS Monograph
editor
Perch, M ; Meloni, F and Vos, R
volume
2024
pages
277 - 285
publisher
European Respiratory Society
external identifiers
  • scopus:85217878016
ISSN
2312-508X
DOI
10.1183/2312508X.10004924
language
English
LU publication?
yes
additional info
Publisher Copyright: © ERS 2024.
id
31d25e87-0ee9-4862-aa6b-4d2a5546968c
date added to LUP
2025-04-02 09:33:02
date last changed
2025-04-04 14:03:58
@inbook{31d25e87-0ee9-4862-aa6b-4d2a5546968c,
  abstract     = {{<p>LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine grafts, presents a promising solution. Additionally, the development of artificial lungs offers another avenue to address the shortage. Artificial lung devices, ranging from extracorporeal to implantable systems, aim to provide temporary or permanent respiratory support, potentially reducing the reliance on human donors. This chapter also discusses the role of gene and cell therapies in enhancing the function and survival of transplanted lungs. Ex vivo lung perfusion platforms are highlighted for their utility in delivering these therapies, optimising graft condition before transplantation. The integration of these bioengineering innovations could significantly impact the future of LTx, offering new lifelines to patients in need.</p>}},
  author       = {{Lindstedt, Sandra and Perch, Michael and Meloni, Federica and Niroomand, Anna}},
  booktitle    = {{Lung Transplantation}},
  editor       = {{Perch, M and Meloni, F and Vos, R}},
  issn         = {{2312-508X}},
  language     = {{eng}},
  pages        = {{277--285}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERS Monograph}},
  title        = {{New frontiers in lung transplantation : a bioengineering perspective}},
  url          = {{http://dx.doi.org/10.1183/2312508X.10004924}},
  doi          = {{10.1183/2312508X.10004924}},
  volume       = {{2024}},
  year         = {{2024}},
}