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Patients above sixty years of age with Hodgkin's lymphoma treated with a new strategy

Enblad, G; Gustavsson, Anita LU ; Sundstrom, C and Glimelius, B (2002) In Acta Oncologica 41(7-8). p.659-667
Abstract
In the Swedish National Care Programme for Hodgkin's lymphoma (HL) a less intensive chemotherapy regimen with individualized dosing (LVPP/OEPA) was introduced in 1989. In total, 139 patients, 77 between 1985 and 1988 and 62 between 1989 and 1992, were studied. Mean ages were 72 and 71 years, respectively. One hundred and nineteen patients were treated with curative intention, 63 (82%) between 1985 and 1988 vs. 56 (90%) between 1989 and 1992 (p = 0.11). All patients (13 vs. 20) treated with radiotherapy only achieved a complete remission (CR). The CR rates (67% vs. 65%) for patients treated with 6-8 cycles of chemotherapy were also similar in the two time periods. The 5-year survival rate was 45% in the period 1985-1988 and 48% in... (More)
In the Swedish National Care Programme for Hodgkin's lymphoma (HL) a less intensive chemotherapy regimen with individualized dosing (LVPP/OEPA) was introduced in 1989. In total, 139 patients, 77 between 1985 and 1988 and 62 between 1989 and 1992, were studied. Mean ages were 72 and 71 years, respectively. One hundred and nineteen patients were treated with curative intention, 63 (82%) between 1985 and 1988 vs. 56 (90%) between 1989 and 1992 (p = 0.11). All patients (13 vs. 20) treated with radiotherapy only achieved a complete remission (CR). The CR rates (67% vs. 65%) for patients treated with 6-8 cycles of chemotherapy were also similar in the two time periods. The 5-year survival rate was 45% in the period 1985-1988 and 48% in 1989-1992. The survival of elderly HL patients was thus not improved from 1985-1988 to 1989-1992. Thus efforts to improve the chemotherapy regimen with individualized dosing did not change the outcome. Many patients experienced myelosuppression and opportunistic infections that may have contributed to the poor treatment results. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
41
issue
7-8
pages
659 - 667
publisher
Taylor & Francis
external identifiers
  • wos:000180429400012
  • pmid:14651211
  • scopus:0346665810
ISSN
1651-226X
DOI
10.1080/028418602321028283
language
English
LU publication?
yes
id
710757fa-d2ac-46a8-9699-433dcde31f58 (old id 320057)
date added to LUP
2007-08-17 07:55:30
date last changed
2017-01-01 07:04:16
@article{710757fa-d2ac-46a8-9699-433dcde31f58,
  abstract     = {In the Swedish National Care Programme for Hodgkin's lymphoma (HL) a less intensive chemotherapy regimen with individualized dosing (LVPP/OEPA) was introduced in 1989. In total, 139 patients, 77 between 1985 and 1988 and 62 between 1989 and 1992, were studied. Mean ages were 72 and 71 years, respectively. One hundred and nineteen patients were treated with curative intention, 63 (82%) between 1985 and 1988 vs. 56 (90%) between 1989 and 1992 (p = 0.11). All patients (13 vs. 20) treated with radiotherapy only achieved a complete remission (CR). The CR rates (67% vs. 65%) for patients treated with 6-8 cycles of chemotherapy were also similar in the two time periods. The 5-year survival rate was 45% in the period 1985-1988 and 48% in 1989-1992. The survival of elderly HL patients was thus not improved from 1985-1988 to 1989-1992. Thus efforts to improve the chemotherapy regimen with individualized dosing did not change the outcome. Many patients experienced myelosuppression and opportunistic infections that may have contributed to the poor treatment results.},
  author       = {Enblad, G and Gustavsson, Anita and Sundstrom, C and Glimelius, B},
  issn         = {1651-226X},
  language     = {eng},
  number       = {7-8},
  pages        = {659--667},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Patients above sixty years of age with Hodgkin's lymphoma treated with a new strategy},
  url          = {http://dx.doi.org/10.1080/028418602321028283},
  volume       = {41},
  year         = {2002},
}