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Cell lineage dynamics in stratified shoot apical meristems

Pineda, Mario LU and Lehtila, K (2002) In Journal of Theoretical Biology 219(4). p.495-505
Abstract
We devise a stochastic and spatially explicit model for the dynamics of the initials cells in a stratified shoot apical meristem (SAM). The meristem is composed of three layers with seven initials per layer. We investigate the probability and number of divisions for a mutant lineage to either reach fixation or becoming purged through selection or drift. In contrast to previous studies our results show that the functional organization of the initials in stratified SAMs acts as an efficient purging mechanism particularly of deleterious mutations. All mutants are rapidly purged when deleterious. The probability of fixation for mutants with a higher fitness than the wild type increases linearly up to 70%. The median number of divisions to... (More)
We devise a stochastic and spatially explicit model for the dynamics of the initials cells in a stratified shoot apical meristem (SAM). The meristem is composed of three layers with seven initials per layer. We investigate the probability and number of divisions for a mutant lineage to either reach fixation or becoming purged through selection or drift. In contrast to previous studies our results show that the functional organization of the initials in stratified SAMs acts as an efficient purging mechanism particularly of deleterious mutations. All mutants are rapidly purged when deleterious. The probability of fixation for mutants with a higher fitness than the wild type increases linearly up to 70%. The median number of divisions to fixation of both genotypes is insensitive to the mutant's fitness. The median number of divisions to wildtype fixation is less than 100, with the upper quartile below 200. The largest number of divisions to wild-type fixation are in the order of 100 000 divisions. Our results indicate that the spatial organization of SAM enables the efficient purging of mutant lineages, particularly if they are deleterious. On the other hand, long-lived chimeric stages are common when mutant lineages succeed to overcome the initial numerical disadvantage. (C) 2002 Elsevier Science Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Theoretical Biology
volume
219
issue
4
pages
495 - 505
publisher
Academic Press
external identifiers
  • wos:000180312900005
  • pmid:12425981
  • scopus:0036431857
ISSN
1095-8541
DOI
10.1006/jtbi.2002.3139
language
English
LU publication?
yes
id
dfe686a8-4ede-462f-8cb2-4d2d9a0527d1 (old id 320276)
date added to LUP
2007-11-09 07:36:45
date last changed
2017-01-01 07:10:48
@article{dfe686a8-4ede-462f-8cb2-4d2d9a0527d1,
  abstract     = {We devise a stochastic and spatially explicit model for the dynamics of the initials cells in a stratified shoot apical meristem (SAM). The meristem is composed of three layers with seven initials per layer. We investigate the probability and number of divisions for a mutant lineage to either reach fixation or becoming purged through selection or drift. In contrast to previous studies our results show that the functional organization of the initials in stratified SAMs acts as an efficient purging mechanism particularly of deleterious mutations. All mutants are rapidly purged when deleterious. The probability of fixation for mutants with a higher fitness than the wild type increases linearly up to 70%. The median number of divisions to fixation of both genotypes is insensitive to the mutant's fitness. The median number of divisions to wildtype fixation is less than 100, with the upper quartile below 200. The largest number of divisions to wild-type fixation are in the order of 100 000 divisions. Our results indicate that the spatial organization of SAM enables the efficient purging of mutant lineages, particularly if they are deleterious. On the other hand, long-lived chimeric stages are common when mutant lineages succeed to overcome the initial numerical disadvantage. (C) 2002 Elsevier Science Ltd. All rights reserved.},
  author       = {Pineda, Mario and Lehtila, K},
  issn         = {1095-8541},
  language     = {eng},
  number       = {4},
  pages        = {495--505},
  publisher    = {Academic Press},
  series       = {Journal of Theoretical Biology},
  title        = {Cell lineage dynamics in stratified shoot apical meristems},
  url          = {http://dx.doi.org/10.1006/jtbi.2002.3139},
  volume       = {219},
  year         = {2002},
}