Advanced

Cadmium in blood and urine - Impact of sex, age, dietary intake, iron status, and former smoking - Association of renal effects

Olsson, Ing-Marie; Bensryd, Inger LU ; Lundh, Thomas LU ; Ottosson, Helene LU ; Skerfving, Staffan LU and Oskarsson, A (2002) In Environmental Health Perspectives 110(12). p.1185-1190
Abstract
We studied determinants of cadmium status and kidney function in nonsmoking men and women living on farms in southern Sweden. Median blood Cd (BCd) was 1.8 nmol/L (range, 0.38-18) and median urinary Cd (UCd) was 0.23 nmol/mmol creatinine (range, 0.065-0.99). The intake of Cd per kilogram body weight did not significantly differ between sexes and did not correlate with BCd or UCd, which may be explained by a low and varying bioavailibility of Cd from food items. However, when a subgroup of the study population, couples of never-smoking men and women, were compared, a lower intake per kilogram body weight was found in the women, but the women had a 1.8 times higher BCd and a 1.4 times higher UCd. The higher female BCd and UCd may be... (More)
We studied determinants of cadmium status and kidney function in nonsmoking men and women living on farms in southern Sweden. Median blood Cd (BCd) was 1.8 nmol/L (range, 0.38-18) and median urinary Cd (UCd) was 0.23 nmol/mmol creatinine (range, 0.065-0.99). The intake of Cd per kilogram body weight did not significantly differ between sexes and did not correlate with BCd or UCd, which may be explained by a low and varying bioavailibility of Cd from food items. However, when a subgroup of the study population, couples of never-smoking men and women, were compared, a lower intake per kilogram body weight was found in the women, but the women had a 1.8 times higher BCd and a 1.4 times higher UCd. The higher female BCd and UCd may be explained by higher absorption due to low iron status. BCd and UCd both increased with age and were higher in the ex-smokers, who had stopped smoking more than 5 years before the study, compared to never-smokers. The contribution of locally produced food to the total Cd intake was relatively low and varied. Males living in areas with low soil Cd had lower UCd than the others. However, Cd levels in kidneys from pigs, fed locally produced cereals, did not predict BCd or UCd in humans at the same farms. The kidney function parameter beta(2)-microglobulin-creatinine clearance was related to UCd, whereas urinary protein-HC, N-acetyl-beta-glucoseaminidase or albumin-creatinine clearance was not when age was accounted for. Hence, even. at the, low exposure levels in this study population, there was an indication of effect on biochemical markers of renal function. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
N-acetyl-beta-glucoseaminidase, kidney, alpha(1)-microglobulin, beta(2)-microglobulin, protein-HC, serum ferritin
in
Environmental Health Perspectives
volume
110
issue
12
pages
1185 - 1190
publisher
National Institute of Environmental Health Science
external identifiers
  • wos:000179810600020
  • pmid:12460796
  • scopus:0036917667
ISSN
1552-9924
language
English
LU publication?
yes
id
e8eee67d-c543-45a0-9a0d-b69e05955c0c (old id 321790)
alternative location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241104/
date added to LUP
2007-11-02 14:23:01
date last changed
2017-11-05 04:28:56
@article{e8eee67d-c543-45a0-9a0d-b69e05955c0c,
  abstract     = {We studied determinants of cadmium status and kidney function in nonsmoking men and women living on farms in southern Sweden. Median blood Cd (BCd) was 1.8 nmol/L (range, 0.38-18) and median urinary Cd (UCd) was 0.23 nmol/mmol creatinine (range, 0.065-0.99). The intake of Cd per kilogram body weight did not significantly differ between sexes and did not correlate with BCd or UCd, which may be explained by a low and varying bioavailibility of Cd from food items. However, when a subgroup of the study population, couples of never-smoking men and women, were compared, a lower intake per kilogram body weight was found in the women, but the women had a 1.8 times higher BCd and a 1.4 times higher UCd. The higher female BCd and UCd may be explained by higher absorption due to low iron status. BCd and UCd both increased with age and were higher in the ex-smokers, who had stopped smoking more than 5 years before the study, compared to never-smokers. The contribution of locally produced food to the total Cd intake was relatively low and varied. Males living in areas with low soil Cd had lower UCd than the others. However, Cd levels in kidneys from pigs, fed locally produced cereals, did not predict BCd or UCd in humans at the same farms. The kidney function parameter beta(2)-microglobulin-creatinine clearance was related to UCd, whereas urinary protein-HC, N-acetyl-beta-glucoseaminidase or albumin-creatinine clearance was not when age was accounted for. Hence, even. at the, low exposure levels in this study population, there was an indication of effect on biochemical markers of renal function.},
  author       = {Olsson, Ing-Marie and Bensryd, Inger and Lundh, Thomas and Ottosson, Helene and Skerfving, Staffan and Oskarsson, A},
  issn         = {1552-9924},
  keyword      = {N-acetyl-beta-glucoseaminidase,kidney,alpha(1)-microglobulin,beta(2)-microglobulin,protein-HC,serum ferritin},
  language     = {eng},
  number       = {12},
  pages        = {1185--1190},
  publisher    = {National Institute of Environmental Health Science},
  series       = {Environmental Health Perspectives},
  title        = {Cadmium in blood and urine - Impact of sex, age, dietary intake, iron status, and former smoking - Association of renal effects},
  volume       = {110},
  year         = {2002},
}