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SNP array and FISH findings in two pleomorphic hyalinizing angiectatic tumors.

Mohajeri, Arezoo; Kindblom, Lars-Gunnar; Sumathi, Vaiyapuri P; Brosjö, Otte; Magnusson, Linda LU ; Nilsson, Jenny LU ; Hansén Nord, Karolin LU and Mertens, Fredrik LU (2012) In Cancer genetics 205(12). p.6-673
Abstract
Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare soft tissue tumor of intermediate malignancy and uncertain cellular origin and lineage of differentiation. Although PHAT is still poorly characterized at the genetic level, there is a potential genetic overlap with two other soft tissue tumors: myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic fibrolipomatous tumor (HFLT); MIFS and HFLT share a characteristic t(1;10)(p22;q24) with breakpoints in the TGFBR3 locus on chromosome 1 and near the MGEA5 locus on chromosome 10. Recently, a PHAT with a similar t(1;10) was reported, suggesting a genetic link between MIFS/HFLT and PHAT. To ascertain whether PHAT is also associated with this translocation, two cases were subjected... (More)
Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare soft tissue tumor of intermediate malignancy and uncertain cellular origin and lineage of differentiation. Although PHAT is still poorly characterized at the genetic level, there is a potential genetic overlap with two other soft tissue tumors: myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic fibrolipomatous tumor (HFLT); MIFS and HFLT share a characteristic t(1;10)(p22;q24) with breakpoints in the TGFBR3 locus on chromosome 1 and near the MGEA5 locus on chromosome 10. Recently, a PHAT with a similar t(1;10) was reported, suggesting a genetic link between MIFS/HFLT and PHAT. To ascertain whether PHAT is also associated with this translocation, two cases were subjected to single nucleotide polymorphism (SNP) array and fluorescence in situ hybridization analyses. Neither PHAT showed a t(1;10) or other types of rearrangement of the TGFBR3 or MGEA5 loci. Both tumors showed imbalances in the SNP array analysis, but none was shared. Thus, the results indicate that PHAT is genetically distinguishable from MIFS and HFLT, but further studies are needed to identify the salient genetic pathways involved in PHAT development. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Cancer genetics
volume
205
issue
12
pages
6 - 673
publisher
Elsevier
external identifiers
  • wos:000313929200010
  • pmid:23177593
  • scopus:84872031022
ISSN
2210-7762
DOI
10.1016/j.cancergen.2012.10.008
language
English
LU publication?
yes
id
a9384ae2-19cf-4a68-95f2-8949f9936d02 (old id 3218540)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23177593?dopt=Abstract
date added to LUP
2012-12-03 22:20:13
date last changed
2017-10-22 04:56:03
@article{a9384ae2-19cf-4a68-95f2-8949f9936d02,
  abstract     = {Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare soft tissue tumor of intermediate malignancy and uncertain cellular origin and lineage of differentiation. Although PHAT is still poorly characterized at the genetic level, there is a potential genetic overlap with two other soft tissue tumors: myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic fibrolipomatous tumor (HFLT); MIFS and HFLT share a characteristic t(1;10)(p22;q24) with breakpoints in the TGFBR3 locus on chromosome 1 and near the MGEA5 locus on chromosome 10. Recently, a PHAT with a similar t(1;10) was reported, suggesting a genetic link between MIFS/HFLT and PHAT. To ascertain whether PHAT is also associated with this translocation, two cases were subjected to single nucleotide polymorphism (SNP) array and fluorescence in situ hybridization analyses. Neither PHAT showed a t(1;10) or other types of rearrangement of the TGFBR3 or MGEA5 loci. Both tumors showed imbalances in the SNP array analysis, but none was shared. Thus, the results indicate that PHAT is genetically distinguishable from MIFS and HFLT, but further studies are needed to identify the salient genetic pathways involved in PHAT development.},
  author       = {Mohajeri, Arezoo and Kindblom, Lars-Gunnar and Sumathi, Vaiyapuri P and Brosjö, Otte and Magnusson, Linda and Nilsson, Jenny and Hansén Nord, Karolin and Mertens, Fredrik},
  issn         = {2210-7762},
  language     = {eng},
  month        = {11},
  number       = {12},
  pages        = {6--673},
  publisher    = {Elsevier},
  series       = {Cancer genetics},
  title        = {SNP array and FISH findings in two pleomorphic hyalinizing angiectatic tumors.},
  url          = {http://dx.doi.org/10.1016/j.cancergen.2012.10.008},
  volume       = {205},
  year         = {2012},
}