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History of depression prior to Alzheimer's disease and vascular dementia verified post-mortem.

Brunnström, Hans LU ; Passant, Ulla LU ; Englund, Elisabet LU and Gustafson, Lars LU (2013) In Archives of Gerontology and Geriatrics 56(1). p.80-84
Abstract
The aim of this study was to analyze the medical history, with regards to previous remote depression, in patients with neuropathologically verified Alzheimer's disease (AD), vascular dementia (VaD) and mixed AD/VaD. The 201 patients included (115 AD, 44 VaD and 42 mixed AD/VaD) had been referred to the Psychogeriatric/Psychiatric Department, Lund University Hospital, for psychogeriatric investigation and were followed-up with clinical records and detailed information on psychiatric history prior to the onset of dementia. Depression was considered to exist when the patient had consulted a psychiatrist or physician and had been diagnosed with a "depressive episode" or "depression" and when anti-depressants and/or other specific treatments... (More)
The aim of this study was to analyze the medical history, with regards to previous remote depression, in patients with neuropathologically verified Alzheimer's disease (AD), vascular dementia (VaD) and mixed AD/VaD. The 201 patients included (115 AD, 44 VaD and 42 mixed AD/VaD) had been referred to the Psychogeriatric/Psychiatric Department, Lund University Hospital, for psychogeriatric investigation and were followed-up with clinical records and detailed information on psychiatric history prior to the onset of dementia. Depression was considered to exist when the patient had consulted a psychiatrist or physician and had been diagnosed with a "depressive episode" or "depression" and when anti-depressants and/or other specific treatments had been prescribed. Twenty patients (10%) had suffered from depression earlier in life well before the onset of dementia. Eight of the 9 AD patients with a previous diagnosis of depression had suffered from only one depressive episode and all had responded well to treatment, with complete recovery. In the VaD group, 8 out of 9 patients suffered two or more depressive episodes and only two recovered completely. Events with a possible significant relationship to depression were seen in 8 of the 9 AD patients but in only 1 of the 9 VaD patients. Psychotic symptoms were more common in VaD than in the AD group. The treatment modality of depression was similar in the groups. In conclusion, a history of depression prior to dementia is more common and more therapy-resistant in VaD than in AD. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Archives of Gerontology and Geriatrics
volume
56
issue
1
pages
80 - 84
publisher
Elsevier
external identifiers
  • wos:000311343300014
  • pmid:23116976
  • scopus:84869493724
ISSN
1872-6976
DOI
10.1016/j.archger.2012.10.008
language
English
LU publication?
yes
id
569781e7-dad0-4306-8f76-f7b417d2ac7d (old id 3219323)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23116976?dopt=Abstract
date added to LUP
2012-12-03 11:50:06
date last changed
2017-04-16 04:25:01
@article{569781e7-dad0-4306-8f76-f7b417d2ac7d,
  abstract     = {The aim of this study was to analyze the medical history, with regards to previous remote depression, in patients with neuropathologically verified Alzheimer's disease (AD), vascular dementia (VaD) and mixed AD/VaD. The 201 patients included (115 AD, 44 VaD and 42 mixed AD/VaD) had been referred to the Psychogeriatric/Psychiatric Department, Lund University Hospital, for psychogeriatric investigation and were followed-up with clinical records and detailed information on psychiatric history prior to the onset of dementia. Depression was considered to exist when the patient had consulted a psychiatrist or physician and had been diagnosed with a "depressive episode" or "depression" and when anti-depressants and/or other specific treatments had been prescribed. Twenty patients (10%) had suffered from depression earlier in life well before the onset of dementia. Eight of the 9 AD patients with a previous diagnosis of depression had suffered from only one depressive episode and all had responded well to treatment, with complete recovery. In the VaD group, 8 out of 9 patients suffered two or more depressive episodes and only two recovered completely. Events with a possible significant relationship to depression were seen in 8 of the 9 AD patients but in only 1 of the 9 VaD patients. Psychotic symptoms were more common in VaD than in the AD group. The treatment modality of depression was similar in the groups. In conclusion, a history of depression prior to dementia is more common and more therapy-resistant in VaD than in AD.},
  author       = {Brunnström, Hans and Passant, Ulla and Englund, Elisabet and Gustafson, Lars},
  issn         = {1872-6976},
  language     = {eng},
  number       = {1},
  pages        = {80--84},
  publisher    = {Elsevier},
  series       = {Archives of Gerontology and Geriatrics},
  title        = {History of depression prior to Alzheimer's disease and vascular dementia verified post-mortem.},
  url          = {http://dx.doi.org/10.1016/j.archger.2012.10.008},
  volume       = {56},
  year         = {2013},
}