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Calcium in Cell-Extracellular Matrix Interactions

Gopal, Sandeep LU orcid ; Multhaupt, Hinke A B and Couchman, John R (2020) In Advances in Experimental Medicine and Biology 1131. p.1079-1102
Abstract

In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

Please use this url to cite or link to this publication:
author
; and
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Animals, Calcium/metabolism, Cell Movement, Extracellular Matrix/metabolism, Extracellular Matrix Proteins/metabolism
host publication
Calcium signaling
series title
Advances in Experimental Medicine and Biology
editor
Islam, Md Shahidul
volume
1131
edition
2
pages
24 pages
publisher
Springer Nature
external identifiers
  • pmid:31646546
  • scopus:85074084646
ISSN
0065-2598
ISBN
9783030124571
DOI
10.1007/978-3-030-12457-1_43
language
English
LU publication?
no
id
32424632-3195-4db7-bfe7-34e4387e38c4
date added to LUP
2021-10-25 13:04:26
date last changed
2024-04-20 13:57:47
@inbook{32424632-3195-4db7-bfe7-34e4387e38c4,
  abstract     = {{<p>In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.</p>}},
  author       = {{Gopal, Sandeep and Multhaupt, Hinke A B and Couchman, John R}},
  booktitle    = {{Calcium signaling}},
  editor       = {{Islam, Md Shahidul}},
  isbn         = {{9783030124571}},
  issn         = {{0065-2598}},
  keywords     = {{Animals; Calcium/metabolism; Cell Movement; Extracellular Matrix/metabolism; Extracellular Matrix Proteins/metabolism}},
  language     = {{eng}},
  pages        = {{1079--1102}},
  publisher    = {{Springer Nature}},
  series       = {{Advances in Experimental Medicine and Biology}},
  title        = {{Calcium in Cell-Extracellular Matrix Interactions}},
  url          = {{http://dx.doi.org/10.1007/978-3-030-12457-1_43}},
  doi          = {{10.1007/978-3-030-12457-1_43}},
  volume       = {{1131}},
  year         = {{2020}},
}