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Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants

Kharazmi, Elham; da Silva Filho, Miguel I.; Pukkala, Eero; Sundquist, Kristina LU ; Thomsen, Hauke and Hemminki, Kari LU (2012) In British Journal of Haematology 159(5). p.585-588
Abstract
Despite recent successes in the identification of genetic susceptibility loci, no familial risk has been demonstrated for childhood acute lymphoblastic leukaemia (ALL). We identified 3994 childhood ALL cases from two cancer registries; family members were obtained from population registers. The standardized incidence ratio for familial risk in singleton siblings and twins was 3.2 (95% confidence interval 1.55.9) and 162.6 (70.2320.4), respectively. The present data constitute the first demonstration of familial risk for singleton siblings; the high risk for twins is believed to result from shared prenatal blood circulation. The data suggest that currently unidentified genetic loci underlie these observed familial effects.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
familial cancer, standardized incidence ratio, childhood acute, lymphocytic leukaemia, susceptibility genes
in
British Journal of Haematology
volume
159
issue
5
pages
585 - 588
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000310980700014
  • scopus:84869086592
ISSN
0007-1048
DOI
10.1111/bjh.12069
language
English
LU publication?
yes
id
8c02b38e-6842-43bc-81a7-7a0e9cac998b (old id 3243059)
date added to LUP
2013-01-07 09:32:52
date last changed
2017-09-24 03:16:26
@article{8c02b38e-6842-43bc-81a7-7a0e9cac998b,
  abstract     = {Despite recent successes in the identification of genetic susceptibility loci, no familial risk has been demonstrated for childhood acute lymphoblastic leukaemia (ALL). We identified 3994 childhood ALL cases from two cancer registries; family members were obtained from population registers. The standardized incidence ratio for familial risk in singleton siblings and twins was 3.2 (95% confidence interval 1.55.9) and 162.6 (70.2320.4), respectively. The present data constitute the first demonstration of familial risk for singleton siblings; the high risk for twins is believed to result from shared prenatal blood circulation. The data suggest that currently unidentified genetic loci underlie these observed familial effects.},
  author       = {Kharazmi, Elham and da Silva Filho, Miguel I. and Pukkala, Eero and Sundquist, Kristina and Thomsen, Hauke and Hemminki, Kari},
  issn         = {0007-1048},
  keyword      = {familial cancer,standardized incidence ratio,childhood acute,lymphocytic leukaemia,susceptibility genes},
  language     = {eng},
  number       = {5},
  pages        = {585--588},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants},
  url          = {http://dx.doi.org/10.1111/bjh.12069},
  volume       = {159},
  year         = {2012},
}