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Transient mechanical benefits of a deep inflation in the injured mouse lung

Allen, G; Lundblad, Lennart LU ; Parsons, P and Bates, JHT (2002) In Journal of Applied Physiology 93(5). p.1709-1715
Abstract
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total... (More)
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atelectasis, recruitment, positive-pressure respiration, elastance, acute lung injury
in
Journal of Applied Physiology
volume
93
issue
5
pages
1709 - 1715
publisher
American Physiological Society
external identifiers
  • wos:000178744400019
  • pmid:12381758
  • scopus:0036871985
ISSN
1522-1601
DOI
10.1152/japplphysiol.00473.2002
language
English
LU publication?
yes
id
1ea11472-af66-4952-8d19-0f4d84940098 (old id 324954)
date added to LUP
2007-08-06 14:51:48
date last changed
2017-08-06 03:40:12
@article{1ea11472-af66-4952-8d19-0f4d84940098,
  abstract     = {The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P &lt; 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.},
  author       = {Allen, G and Lundblad, Lennart and Parsons, P and Bates, JHT},
  issn         = {1522-1601},
  keyword      = {atelectasis,recruitment,positive-pressure respiration,elastance,acute lung injury},
  language     = {eng},
  number       = {5},
  pages        = {1709--1715},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Transient mechanical benefits of a deep inflation in the injured mouse lung},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00473.2002},
  volume       = {93},
  year         = {2002},
}