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Transient mechanical benefits of a deep inflation in the injured mouse lung

Allen, G ; Lundblad, Lennart LU ; Parsons, P and Bates, JHT (2002) In Journal of Applied Physiology 93(5). p.1709-1715
Abstract
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total... (More)
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atelectasis, recruitment, positive-pressure respiration, elastance, acute lung injury
in
Journal of Applied Physiology
volume
93
issue
5
pages
1709 - 1715
publisher
American Physiological Society
external identifiers
  • wos:000178744400019
  • pmid:12381758
  • scopus:0036871985
  • pmid:12381758
ISSN
1522-1601
DOI
10.1152/japplphysiol.00473.2002
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Physiology (013242300), Clinical Physiology and Nuclear Medicine Unit (013242320)
id
1ea11472-af66-4952-8d19-0f4d84940098 (old id 324954)
date added to LUP
2016-04-01 12:03:40
date last changed
2023-09-01 17:51:13
@article{1ea11472-af66-4952-8d19-0f4d84940098,
  abstract     = {{The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P &lt; 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.}},
  author       = {{Allen, G and Lundblad, Lennart and Parsons, P and Bates, JHT}},
  issn         = {{1522-1601}},
  keywords     = {{atelectasis; recruitment; positive-pressure respiration; elastance; acute lung injury}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1709--1715}},
  publisher    = {{American Physiological Society}},
  series       = {{Journal of Applied Physiology}},
  title        = {{Transient mechanical benefits of a deep inflation in the injured mouse lung}},
  url          = {{http://dx.doi.org/10.1152/japplphysiol.00473.2002}},
  doi          = {{10.1152/japplphysiol.00473.2002}},
  volume       = {{93}},
  year         = {{2002}},
}