Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene
(2002) In Eukaryotic Cell 1(5). p.823-829- Abstract
- The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism... (More)
- The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism of conidiation induction is presented according to which the mycelium produces a conidiation inducer (conidiogenone) that accumulates extracellularly. When a threshold concentration is reached, induction likely takes place by interaction with a specific cellular receptor. The results indicate that conidiogenone is both sufficient and necessary to induce conidiation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/325031
- author
- Roncal, T ; Cordobes, S ; Sterner, Olov LU and Ugalde, U
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Eukaryotic Cell
- volume
- 1
- issue
- 5
- pages
- 823 - 829
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:12455699
- wos:000178771200015
- scopus:0036778398
- ISSN
- 1535-9778
- DOI
- 10.1128/EC.1.5.823-829.2002
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 2ac7f2a2-bff7-4d5d-b85a-4ff6a6593ba9 (old id 325031)
- date added to LUP
- 2016-04-01 12:21:54
- date last changed
- 2022-03-28 23:57:08
@article{2ac7f2a2-bff7-4d5d-b85a-4ff6a6593ba9,
abstract = {{The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism of conidiation induction is presented according to which the mycelium produces a conidiation inducer (conidiogenone) that accumulates extracellularly. When a threshold concentration is reached, induction likely takes place by interaction with a specific cellular receptor. The results indicate that conidiogenone is both sufficient and necessary to induce conidiation.}},
author = {{Roncal, T and Cordobes, S and Sterner, Olov and Ugalde, U}},
issn = {{1535-9778}},
language = {{eng}},
number = {{5}},
pages = {{823--829}},
publisher = {{American Society for Microbiology}},
series = {{Eukaryotic Cell}},
title = {{Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene}},
url = {{http://dx.doi.org/10.1128/EC.1.5.823-829.2002}},
doi = {{10.1128/EC.1.5.823-829.2002}},
volume = {{1}},
year = {{2002}},
}