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Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene

Roncal, T; Cordobes, S; Sterner, Olov LU and Ugalde, U (2002) In Eukaryotic Cell 1(5). p.823-829
Abstract
The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism... (More)
The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism of conidiation induction is presented according to which the mycelium produces a conidiation inducer (conidiogenone) that accumulates extracellularly. When a threshold concentration is reached, induction likely takes place by interaction with a specific cellular receptor. The results indicate that conidiogenone is both sufficient and necessary to induce conidiation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Eukaryotic Cell
volume
1
issue
5
pages
823 - 829
publisher
American Society for Microbiology
external identifiers
  • pmid:12455699
  • wos:000178771200015
  • scopus:0036778398
ISSN
1535-9778
DOI
10.1128/EC.1.5.823-829.2002
language
English
LU publication?
yes
id
2ac7f2a2-bff7-4d5d-b85a-4ff6a6593ba9 (old id 325031)
date added to LUP
2007-11-12 12:12:50
date last changed
2017-05-14 03:38:26
@article{2ac7f2a2-bff7-4d5d-b85a-4ff6a6593ba9,
  abstract     = {The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism of conidiation induction is presented according to which the mycelium produces a conidiation inducer (conidiogenone) that accumulates extracellularly. When a threshold concentration is reached, induction likely takes place by interaction with a specific cellular receptor. The results indicate that conidiogenone is both sufficient and necessary to induce conidiation.},
  author       = {Roncal, T and Cordobes, S and Sterner, Olov and Ugalde, U},
  issn         = {1535-9778},
  language     = {eng},
  number       = {5},
  pages        = {823--829},
  publisher    = {American Society for Microbiology},
  series       = {Eukaryotic Cell},
  title        = {Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene},
  url          = {http://dx.doi.org/10.1128/EC.1.5.823-829.2002},
  volume       = {1},
  year         = {2002},
}