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Platinum(II) and gold(I) complexes based on 1,1 '-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes

Bjelosevic, Haris LU ; Guzei, Ilia A.; Spencer, Lara C.; Persson, Tina LU ; Kriel, Frederik H.; Hewer, Raymond; Nell, Margo J.; Gut, Jiri; van Rensburg, Constance E. J. and Rosenthal, Philip J., et al. (2012) In Journal of Organometallic Chemistry 720. p.52-59
Abstract
The synthesis of series of 1,2,1' substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-kappa P-2,P'}bis[chlorogold(I)] (8) (IC50 = 1.40 mu M), {1-[1-(acetoxyethyl)-1',2-bis(diphenylphosphino)ferrocene-kappa P-2,P']bis[chlorogold(1)] (9) (IC50 =... (More)
The synthesis of series of 1,2,1' substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-kappa P-2,P'}bis[chlorogold(I)] (8) (IC50 = 1.40 mu M), {1-[1-(acetoxyethyl)-1',2-bis(diphenylphosphino)ferrocene-kappa P-2,P']bis[chlorogold(1)] (9) (IC50 = 0.51 mu M), {1-[1-(3-carboxypropanamido)ethyl]-1',2-bis(diphenylphosphino)-ruthenocene kappa P-2,P'} bis[chlorogold(I)] (12) (IC50 = 1.784 mu M), have the best activities against cancer, HIV and malaria respectively. (C) 2012 Elsevier B.V. All rights reserved. (Less)
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Bis(diphenylphosphino)ferrocenyl-Bis(diphenylphosphino)ruthenocenyl-, Platinum and gold complexes, Anticancer, AntiHIV, Antimalarial agents
in
Journal of Organometallic Chemistry
volume
720
pages
52 - 59
publisher
Elsevier
external identifiers
  • wos:000310765400008
  • scopus:84867540119
ISSN
0022-328X
DOI
10.1016/j.jorganchem.2012.08.034
language
English
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yes
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0cabb818-3ad4-44a0-b785-e421a8bce404 (old id 3256255)
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2012-12-27 09:23:22
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2017-11-19 03:41:24
@article{0cabb818-3ad4-44a0-b785-e421a8bce404,
  abstract     = {The synthesis of series of 1,2,1' substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-kappa P-2,P'}bis[chlorogold(I)] (8) (IC50 = 1.40 mu M), {1-[1-(acetoxyethyl)-1',2-bis(diphenylphosphino)ferrocene-kappa P-2,P']bis[chlorogold(1)] (9) (IC50 = 0.51 mu M), {1-[1-(3-carboxypropanamido)ethyl]-1',2-bis(diphenylphosphino)-ruthenocene kappa P-2,P'} bis[chlorogold(I)] (12) (IC50 = 1.784 mu M), have the best activities against cancer, HIV and malaria respectively. (C) 2012 Elsevier B.V. All rights reserved.},
  author       = {Bjelosevic, Haris and Guzei, Ilia A. and Spencer, Lara C. and Persson, Tina and Kriel, Frederik H. and Hewer, Raymond and Nell, Margo J. and Gut, Jiri and van Rensburg, Constance E. J. and Rosenthal, Philip J. and Coates, Judy and Darkwa, James and Elmroth, Sofi},
  issn         = {0022-328X},
  keyword      = {Bis(diphenylphosphino)ferrocenyl-Bis(diphenylphosphino)ruthenocenyl-,Platinum and gold complexes,Anticancer,AntiHIV,Antimalarial agents},
  language     = {eng},
  pages        = {52--59},
  publisher    = {Elsevier},
  series       = {Journal of Organometallic Chemistry},
  title        = {Platinum(II) and gold(I) complexes based on 1,1 '-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes},
  url          = {http://dx.doi.org/10.1016/j.jorganchem.2012.08.034},
  volume       = {720},
  year         = {2012},
}