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Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators

Lindstedt, Malin LU ; Johansson Lindbom, Bengt LU and Borrebaeck, Carl LU (2002) In International Immunology 14(10). p.1203-1213
Abstract
Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutation for generating a diverse repertoire of antigen-recognition receptors, it is unlikely that these leukocytes can intrinsically respond to all conceivable molecules present in our environment. In the present study, we have therefore determined how mediators of the inflammatory response regulate global gene transcription in DC. The data represent... (More)
Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutation for generating a diverse repertoire of antigen-recognition receptors, it is unlikely that these leukocytes can intrinsically respond to all conceivable molecules present in our environment. In the present study, we have therefore determined how mediators of the inflammatory response regulate global gene transcription in DC. The data represent an extensive and time-ordered reprogramming of the DC during their course of maturation, involving genes encoding proteins that regulate responses of both innate cells and lymphocytes. This transcriptional reorganization may reflect the effect of in vivo released inflammatory mediators induced by endogenous or pathogenic stimulation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inflammation, immunomodulator, cellular activation, dendritic cell, inflammatory mediator
in
International Immunology
volume
14
issue
10
pages
1203 - 1213
publisher
Oxford University Press
external identifiers
  • pmid:12356685
  • wos:000178557100012
  • scopus:0036796376
ISSN
1460-2377
DOI
10.1093/intimm/dxf082
language
English
LU publication?
yes
id
fb796b84-b98d-48e3-9dc1-956a86b9df8a (old id 325716)
date added to LUP
2007-11-14 16:15:01
date last changed
2017-07-30 03:41:06
@article{fb796b84-b98d-48e3-9dc1-956a86b9df8a,
  abstract     = {Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutation for generating a diverse repertoire of antigen-recognition receptors, it is unlikely that these leukocytes can intrinsically respond to all conceivable molecules present in our environment. In the present study, we have therefore determined how mediators of the inflammatory response regulate global gene transcription in DC. The data represent an extensive and time-ordered reprogramming of the DC during their course of maturation, involving genes encoding proteins that regulate responses of both innate cells and lymphocytes. This transcriptional reorganization may reflect the effect of in vivo released inflammatory mediators induced by endogenous or pathogenic stimulation.},
  author       = {Lindstedt, Malin and Johansson Lindbom, Bengt and Borrebaeck, Carl},
  issn         = {1460-2377},
  keyword      = {inflammation,immunomodulator,cellular activation,dendritic cell,inflammatory mediator},
  language     = {eng},
  number       = {10},
  pages        = {1203--1213},
  publisher    = {Oxford University Press},
  series       = {International Immunology},
  title        = {Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators},
  url          = {http://dx.doi.org/10.1093/intimm/dxf082},
  volume       = {14},
  year         = {2002},
}